Evidence map›Paper›PMID 32632772›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020

Cortical Mechanisms of Single-Pulse Transcranial Magnetic Stimulation in Migraine.

Joseph O Lloyd, Kim I Chisholm, Beatrice Oehle, Martyn G Jones, Bright N Okine, Adnan Al-Kaisy, Giorgio Lambru, Stephen B McMahon, Anna P Andreou

Open access · hybridAbstract read
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Neuromodulation for Headache Management in Pregnancy.Current pain and headache reports · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Devices for Episodic Migraine: Past, Present, and Future.Current pain and headache reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Joseph O LloydHeadache Research-Wolfson CARD, Guy's Campus, King's College London, London, UK.
Kim I ChisholmDepartment of Neurorestoration, Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Beatrice OehleDepartment of Neurorestoration, Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Martyn G JonesDepartment of Neurorestoration, Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Bright N OkineHeadache Research-Wolfson CARD, Guy's Campus, King's College London, London, UK.
Adnan Al-KaisyPain Management and Neuromodulation Centre, Guy's and St Thomas's NHS Foundation Trust, King's Health Partners, London, UK.
Giorgio LambruHeadache Research-Wolfson CARD, Guy's Campus, King's College London, London, UK.
Stephen B McMahonDepartment of Neurorestoration, Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Anna P AndreouHeadache Research-Wolfson CARD, Guy's Campus, King's College London, London, UK. anna.andreou@kcl.ac.uk.ORCID https://orcid.org/0000-0002-7008-6626
King's College London · GBGuy's and St Thomas' NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-pulse transcranial magnetic stimulation (sTMS) of the occipital cortex is an effective migraine treatment. However, its mechanism of action and cortical effects of sTMS in migraine are yet to be elucidated. Using calcium imaging and GCaMP-expressing mice, sTMS did not depolarise neurons and had no effect on vascular tone. Pre-treatment with sTMS, however, significantly affected some characteristics of the cortical spreading depression (CSD) wave, the correlate of migraine aura. sTMS inhibited spontaneous neuronal firing in the visual cortex in a dose-dependent manner and attenuated L-glutamate-evoked firing, but not in the presence of GABA

Indexed as

AnimalsCortical Spreading DepressionFemaleGlutamic AcidIontophoresisMaleMiceMice, Inbred C57BLMigraine DisordersOccipital LobeRatsRats, Sprague-DawleyTranscranial Magnetic StimulationGlutamic AcidcortexGABAglutamateMigrainetranscranial magnetic stimulation

Identifiers

PMID32632772
PMCPMC7851313
OpenAlexW3038780598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.