Evidence map›Paper›PMID 32632728›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2021

Younger Age Is Associated with Improved Survival in Patients Undergoing Liver Transplantation Alone for Metastatic Neuroendocrine Tumors.

Deepa Valvi, Xiaonan Mei, Meera Gupta, Malay B Shah, Alexandre Ancheta, Francesc Marti, Roberto Gedaly

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. [Research progress on liver transplantation therapy for hepatic metastases in gastroenteropancreatic neuroendocrine tumors].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Clinical factors affecting the long-term survival of breast cancer patients.The Journal of international medical research · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Deepa ValviDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.
Xiaonan MeiDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.
Meera GuptaDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.
Malay B ShahDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.
Alexandre AnchetaDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.
Francesc MartiDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA.
Roberto GedalyDepartment of Surgery - Division of Transplantation, University of Kentucky, College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40536, USA. rgeda2@uky.edu.
University of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroendocrine tumor (NET) metastases are a major cause of morbidity and mortality. The role of liver transplantation to treat unresectable metastases from NET is controversial.

methodsWe evaluated outcomes of all patients undergoing "isolated" liver transplantation (LT) for metastatic NETs in the USA, from October 1988 through June 2018 using the UNOS dataset.

resultsDuring the study period, 160,360 LTs were performed. Two hundred six adult patients underwent "isolated" LT for metastatic NETs. The mean (SD) age was 48.2 (11.7) years, ranging from 19 to 75 years; 117 (56.8%) patients were male. Overall 1-, 3-, 5-, and 10-year patient survival rates were 89.1%, 75.3%, 64.9%, and 46.1%, respectively. Tumor recurrence was seen in 70 of 206 patients who underwent LT (34%). The median time to recurrence was 28 months (range, 1 to 192 months) and median wait time for LT was 112 days. Tumor recurrence was significantly higher in transplanted patients waiting less than 6 months compared with those waiting more than 6 months (74.3% vs. 25.7%). Patients' age ≤ 45 years had significantly better survival compared with those > 45 years (p = 0.03). Younger patients with carcinoid tumors had better survival but this trend was not observed in the non-carcinoid group. On multivariable analysis, recipient age, donor age, cold ischemic time MELD score, and tumor recurrence were significant predictors of poor patient survival.

conclusionsWaiting time longer than 6 months is associated to lower rates of tumor recurrence. Younger patients ≤ 45 years had significantly improved survival after LT for NET metastases.

Indexed as

Liver NeoplasmsLiver TransplantationNeuroendocrine TumorsAdultHumansMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeLiver transplantationNET metastases

Identifiers

PMID32632728
OpenAlexW3038726810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.