ArticleEndocrine2020
The D-side of COVID-19: musculoskeletal benefits of vitamin D and beyond.
Article in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Predictive value of C-reactive protein for disease severity and survival in COVID-19 patients: a systematic review and meta-analysis.Clinical and experimental medicine · 2023Pooled it
- Diagnosis and Management of Osteoporosis During COVID-19: Systematic Review and Practical Guidance.Calcified tissue international · 2021Pooled it
- The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis.Metabolism: clinical and experimental · 2021Pooled it
- Serum 25-hydroxyvitamin D levels and health outcomes of hospitalization owing to COVID-19: a retrospective cross-sectional study.The Journal of international medical research · 2024Article
- A Comparison of Cognitive Performance, Depressive Symptoms, and Incidence of Falls in Brazilian Older Women with and without a Confirmed History of COVID-19.International journal of environmental research and public health · 2023Article
- Survival following vertebral compression fractures in population over 65 years old.Aging clinical and experimental research · 2023Article
- COVID-19 Pandemic and Osteoporosis in Elderly Patients.Aging and disease · 2022Article
- Cognitive and balance performance of older adult women during COVID-19 pandemic quarantine: an ex post facto study.Przeglad menopauzalny = Menopause review · 2022Article
- Incidence of hip fractures during the COVID-19 pandemic in the Brazilian public health care system.Archives of osteoporosis · 2022Article
- The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion.Nutrients · 2022Review
- Vertebral fractures and mortality risk in hospitalised patients during the COVID-19 pandemic emergency.Endocrine · 2021Article
- Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?Reviews in endocrine & metabolic disorders · 2021Review
- The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19.Molecules (Basel, Switzerland) · 2021Review
- Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution.Journal of anesthesia, analgesia and critical care · 2021Review
- Secondary prevention of fragility fractures: where do we stand during the COVID-19 pandemic?Journal of endocrinological investigation · 2021Article
- Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors.Experimental gerontology · 2021Review
- Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling.International journal of molecular sciences · 2021Review
- Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India.Annals of medicine and surgery (2012) · 2021Article
- Osteoporosis care amidst the prolonged pandemic.Journal of endocrinological investigation · 2021Review
- COVID-19 and the Endocrine System: A Comprehensive Review on the Theme.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus 2019 disease (COVID-19) mostly adversely affects the elderly, a population at higher risk for low serum 25-hydroxyvitamin D (25(OH)D) levels. In this viewpoint, we highlight the well-known musculoskeletal properties of vitamin D, which are particularly relevant in the context of COVID-19, suggesting further potential benefits through extra-skeletal effects. Maintaining optimal 25(OH)D is crucial to prevent falls, frailty and fractures in elderly patients, with low activity levels due to lockdown, or who are relatively immobilized during hospitalization and after discharge for prolonged periods of time. Hypovitaminosis D is also associated with susceptibility to respiratory infections, admissions to the intensive care unit, and mortality. We underscore the importance of achieving desirable serum 25(OH)D in COVID-19 elderly patients, to ensure beneficial musculoskeletal effects and possibly respiratory effects of vitamin D, in the context of COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.