ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Resting-State fMRI Co-Activation Patterns Reveal Multiscale Brain Functional Alterations in Primary Angle-Closure Glaucoma: Transcriptomic, Cellular, Neurochemical, and Machine-Learning Signatures.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Machine learning with multitype functional connectivity uncovers whole-brain network disruption in primary angle-closure glaucoma.Brain informatics · 2025Article
- Hippocampal subregions functional connectivity alterations in primary angle-closure glaucoma patients with cognitive dysfunction: a resting-state fMRI study.BMC neurology · 2025Article
- Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study.BMJ open ophthalmology · 2025Article
- Association of aberrant brain network connectivity with visual dysfunction in patients with nonarteritic anterior ischemic optic neuropathy: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis.Brain topography · 2024Article
- Arterial spin labeling reveals disordered cerebral perfusion and cerebral blood flow-based functional connectivity in primary open-angle glaucoma.Brain imaging and behavior · 2024Article
- Application of advanced magnetic resonance imaging in glaucoma: a narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Exploration of abnormal dynamic spontaneous brain activity in patients with high myopiaFrontiers in human neuroscience · 2022Article
- Altered functional connectivity of the thalamus in primary angle-closure glaucoma patients: A resting-state fMRI study.Frontiers in neurology · 2022Article
- The Predictive Values of Changes in Local and Remote Brain Functional Connectivity in Primary Angle-Closure Glaucoma Patients According to Support Vector Machine Analysis.Frontiers in human neuroscience · 2022Article
- Altered Brain Activity in Patients With Comitant Strabismus Detected by Analysis of the Fractional Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study.Frontiers in human neuroscience · 2022Article
- Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness.Frontiers in neurology · 2022Article
- Alterations in Spontaneous Neuronal Activity and Microvascular Density of the Optic Nerve Head in Active Thyroid-Associated Ophthalmopathy.Frontiers in endocrinology · 2022Article
- Detection of Abnormal Spontaneous Brain Activity Patterns in Patients With Orbital Fractures Using Fractional Amplitude of Low Frequency Fluctuation.Frontiers in neurology · 2022Article
- Characteristics of the Fractional Amplitude of Low-Frequency Fluctuation in Ocular Hypertension Patients: A Resting-State fMRI Study.Frontiers in medicine · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo explore the alterations of spontaneous neuronal activity and functional connectivity pattern using fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) in patients with primary angle-closure glaucoma (PACG) and fALFF relationship with the glaucoma clinical indices. MATERIALS AND
methodsForty-two PACG patients and 21 normal controls were enrolled in this study. Resting-state functional magnetic resonance imaging was firstly analyzed by fALFF and brain regions with altered fALFF between groups were selected as seeds for the further FC analysis. The relationships between fALFF/FC values of abnormal regions and ophthalmological measures, including mean deviation of visual field (MDVF) and retinal nerve fiber layer (RNFL) thickness, were also analyzed.
resultsCompared with NC, PACG had significant lower fALFF values in the left cuneus, left middle temporal gyrus, right middle temporal gyrus, and right precentral gyrus, while higher fALFF values in the bilateral superior frontal gyrus (P < 0.05 after correction). Furthermore, PACG showed increased FC between left cuneus and bilateral superior frontal gyrus/bilateral posterior cingulate gyrus; between left middle temporal gyrus and bilateral superior frontal gyrus; and between right middle temporal gyrus and bilateral insular (P < 0.05 after correction). In addition, in the PACG group, the mean fALFF values of the left cuneus were positively correlated with MDVF (R = 0.419, P = 0.005) and RNFL thickness (R = 0.322, P = 0.038). Meanwhile, the mean fALFF values of bilateral superior frontal gyrus were negatively correlated with MDVF (R = - 0.454, P = 0.003) and RNFL thickness (R = - 0.556, P < 0.001).
conclusionsPACG exhibited abnormal spontaneous neural activity and connectivity in several brain regions mainly associated with visual and visual-related functions. In addition, the fALFF values of the left cuneus and bilateral superior frontal gyrus may be complementary biomarkers for assessing the disease severity.
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