ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Long-term efficacy and cognitive effects of bilateral hippocampal deep brain stimulation in patients with drug-resistant temporal lobe epilepsy.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Circuit-based neuromodulation for obsessive-compulsive disorder: a systematic review, meta-analysis, and translational case study.Journal of psychiatry & neuroscience : JPN · 2026Pooled it
- Neurostimulation in children with drug-resistant epilepsy: strategies in subcortical targeting and systematic review of the evidence.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Efficacy and safety of deep brain stimulation in drug resistance epilepsy: A systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- The comparison of DBS and RNS for adult drug-resistant epilepsy: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits iniScience · 2026Article
- Cognitive outcomes after deep brain stimulation in drug-resistant epilepsy: A comparison of anterior thalamic and hippocampal stimulation.Epilepsia open · 2025Article
- Deep Brain Stimulation Therapy for Drug-Resistant Epilepsy: Present and Future Perspectives.Journal of epilepsy research · 2025Review
- Research progress of connexins in epileptogensis.Acta epileptologica · 2025Review
- Effect of deep brain stimulation on the severity of seizures and the quality of life in patients with multifocal drug-resistant epilepsy in Iran: A pilot review of local experience.Epilepsy & behavior reports · 2025Article
- Resolution of bilateral temporal lobe epilepsy via minimally invasive stereoelectroencephalogram-guided asymmetric radiofrequency thermocoagulation: a case report.Therapeutic advances in neurological disorders · 2025Article
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- Closed-Loop Adaptive Deep Brain Stimulation in Parkinson's Disease: Procedures to Achieve It and Future Perspectives.Journal of Parkinson's disease · 2023Review
- Acute Effects of High-Frequency Insular Stimulation on Interictal Epileptiform Discharge Rates in Patients with Refractory Epilepsy.Brain sciences · 2022Article
- Role of HMGB1/TLR4 and IL-1β/IL-1R1 Signaling Pathways in Epilepsy.Frontiers in neurology · 2022Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTemporal lobe epilepsy patients treated with hippocampal deep brain stimulation (Hip-DBS) have rarely been reported before. Preoperative and postoperative cognitive function is seldom analyzed.
methodsSeven patients with drug-resistant temporal lobe epilepsy were included in this study. Bilateral Hip-DBS was performed in these patients. The stimulator was activated 1 month after the implantation. Then, the patients returned for further adjustments 4 months after the surgery and reprogramming every year. The seizure frequency, Wechsler Adult Intelligence Scale-IV, and Wechsler memory scale-IV were assessed blindly as the outcomes at each follow-up.
resultsAfter a mean 48-month follow-up, the mean seizure frequency significantly decreased (p = 0.011, paired t test; decrease of 78.1%). One patient (14.3%) was seizure-free by the last follow-up; six of seven (85.7%) patients had reductions in seizure frequency of at least 50%; one patient (14.3%) who did not comply with the antiepileptic drug instructions had a less than 50% reduction in seizure frequency. In addition, there were no significant decreases in intelligence or verbal and visual memory from baseline to the last follow-up (p = 0.736, paired t test; p = 0.380, paired t test, respectively).
conclusionHip-DBS could provide acceptable long-term efficacy and safety. For patients with drug-resistant temporal lobe epilepsy who are not suitable for resective surgery, Hip-DBS could become a potential therapeutic option.
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