ArticleInternational ophthalmology2020
Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study.
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Intraretinal Hyperreflective Foci as an OCT Feature Associated With Retinal Remodeling After Macular Hole Closure.Investigative ophthalmology & visual science · 2026Article
- Photoreceptor Density-Dependent Kinetics of Geographic Atrophy Progression.Ophthalmology science · 2026Article
- Macular Pigment Optical Density Levels Reflect Retinal Remodeling in Lamellar Macular Holes.Investigative ophthalmology & visual science · 2026Observational
- Postoperative Full-Thickness Macular Hole Formation after Vitrectomy for the Removal of Epiretinal Membrane.Korean journal of ophthalmology : KJO · 2025Article
- Histological Assessment of Foveal Mechanical Instability and Potential Implications for Macular Diseases.Investigative ophthalmology & visual science · 2025Article
- Retinal Inflammation and Reactive Müller Cells: Neurotrophins' Release and Neuroprotective Strategies.Biology · 2024Review
- [Lamellar macular holes-In the center of vitreomacular interface diseases : Pathophysiology, spontaneous courses and treatment concepts].Die Ophthalmologie · 2024Review
- MicroRNA-152-3p and MicroRNA-196a-5p Are Downregulated When Müller Cells Are Promoted by Components of the Internal Limiting Membrane: Implications for Macular Hole Healing.International journal of molecular sciences · 2023Article
- Pathophysiology of Secondary Macular Hole in Rhegmatogenous Retinal Detachment.Investigative ophthalmology & visual science · 2023Article
- Baseline demographic, clinical and multimodal imaging features of young patients with type 2 macular telangiectasia.International journal of retina and vitreous · 2023Article
- Internal limiting membrane peeling combined with mouse nerve growth factor injection for idiopathic macular hole.BMC ophthalmology · 2023Article
- Early Optical Coherence Tomography Biomarkers for Selected Retinal Diseases-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- The Role of Müller Cells in Diabetic Macular Edema.Investigative ophthalmology & visual science · 2023Review
- Comparison of long-term visual and anatomical outcomes between internal limiting membrane flap and peeling techniques for macular holes with a propensity score analysis.Eye (London, England) · 2023Article
- Frontiers in diabetic retinal disease.Journal of diabetes and its complications · 2023Review
- A Spontaneous Nonhuman Primate Model of Myopic Foveoschisis.Investigative ophthalmology & visual science · 2023Article
- Indistinct retinal outer layers in the walls of the idiopathic full-thickness macular hole - A potential predictive biomarker for surgical outcomes.Indian journal of ophthalmology · 2022Observational
- Spectral domain OCT features in type 2 macular telangiectasia (type 2 MacTel): its relevance with clinical staging and visual acuity.International journal of retina and vitreous · 2022Article
- Total Neuro-retinal Tubulation (TNT), a novel imaging finding.American journal of ophthalmology case reports · 2022Article
- Modified surgical technique for lamellar macular holes with lamellar hole-associated epiretinal proliferation (LHEP).International ophthalmology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo document with spectral-domain optical coherence tomography the structural stabilization of the fovea and the sealing of outer macular defects by Müller cells.
methodsA retrospective case series of 45 eyes of 34 patients is described.
resultsIn cases of a cystic disruption of the foveola as in macular telangiectasia type 2 and vitreomacular traction, the Müller cell cone provides the structural stability of the fovea. In cases of a detachment or disruption of the Müller cell cone, e.g., in foveal pseudocysts, outer lamellar holes, and degenerative and tractional lamellar holes, Müller cells of the foveal walls may provide the structural stability of the fovea by the formation of a hyperreflective external limiting membrane (ELM) which bridges the holes in the central outer nuclear layer (ONL). Müller cells of the foveal walls and parafovea mediate the regeneration of the foveal architecture in cases of outer lamellar and full-thickness macular holes. The regeneration proceeds by a centripetal displacement of photoreceptor cell somata which closes the holes in the central ONL. The closure may be supported by the formation of a glial tissue band at the ELM which seals the hole.
conclusionsThe Müller cell cone provides the foveal stability in cases of a cystic disruption of the foveola. The structural stability of the outer foveal layers is mainly provided by the Müller cells of the foveal walls and parafovea; these cells also mediate the regeneration of the outer fovea in cases of a defect of the central ONL.
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