Evidence map›Paper›PMID 32632564›Full record

ArticleAnnals of nuclear medicine2020

Visualization of translocator protein (18 kDa) (TSPO) in the retina of diabetic retinopathy rats using fluorine-18-DPA-714.

Yujing Zhou, Yinghui Ou, Zizhao Ju, Xiaoqing Zhang, Lingling Zheng, Jun Li, Yu Sun, Xingdang Liu

Abstract read
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In one paragraph

Article in Annals of nuclear medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yujing ZhouDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Yinghui OuDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Zizhao JuDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Xiaoqing ZhangDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Lingling ZhengDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Jun LiDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Yu SunDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Xingdang LiuDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China. xingdliu@fudan.edu.cn.
Fudan University · CNHuashan Hospital · CN

Funding

National Natural Science Foundation of China Grant 81571706
6 · The paper itself

Abstract

objectivesTo investigate the feasibility of a noninvasive method for imaging translocator protein (18 kDa) (TSPO) in the retina of diabetic retinopathy (DR) rats using fluorine-18-DPA-714 ([

methodsSprague-Dawley (SD) rats were intraperitoneally injected with streptozocin (STZ) (65 mg kg

resultsPET/CT results showed that the SUV of [

conclusionsThe PET results demonstrated that TSPO was decreased in the early stage of DR. [

Indexed as

Fluorine RadioisotopesPositron Emission Tomography Computed TomographyPyrazolesPyrimidinesAnimalsCarrier ProteinsDiabetic RetinopathyGene Expression RegulationMaleRatsRats, Sprague-DawleyReceptors, GABA-ARetinaCarrier ProteinsFluorine-18Fluorine RadioisotopesN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesReceptors, GABA-ATspo protein, rat[18F]-DPA-714Diabetic retinopathyPositron emission tomographyTranslocator protein

Identifiers

PMID32632564
OpenAlexW3039542184

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.