ArticleNature ecology & evolution2020
Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut.
Article in Nature ecology & evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Predicting resistance evolution to guide antibiotic development.Nature reviews. Microbiology · 2026Review
- Modelling the role of the microbiome in antimicrobial resistance across scales.Nature microbiology · 2026Review
- Antibiotic-induced gut microbiome dysbiosis: risks and strategies for mitigation.The EMBO journal · 2026Review
- Eco-evolutionary dynamics and environmental detoxification jointly shape bacterial community response to antibiotic perturbation.The ISME journal · 2026Article
- Clonal interference and genomic repair during strain coexistence in the gut.PLoS genetics · 2025Article
- Article
- Microbiota and metabolic adaptation shapebioRxiv : the preprint server for biology · 2024Article
- Intrahost evolution of the gut microbiota.Nature reviews. Microbiology · 2023Review
- Evolutionary implications of host genetic control for engineering beneficial microbiomes.Current opinion in systems biology · 2023Review
- Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems.Frontiers in nutrition · 2023Review
- The impact of cefuroxime prophylaxis on human intestinal microbiota in surgical oncological patients.Frontiers in microbiomes · 2022Article
- Chicken gut microbiome members limit the spread of an antimicrobial resistance plasmid inProceedings. Biological sciences · 2021Article
- Molecular signatures of resource competition: Clonal interference favors ecological diversification and can lead to incipient speciation.Evolution; international journal of organic evolution · 2021Article
- Gut microbiota response to antibiotics is personalized and depends on baseline microbiota.Microbiome · 2021Article
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 1:EFSA journal. European Food Safety Authority · 2021Article
- The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.FEMS microbiology reviews · 2021Review
- Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner.Nature microbiology · 2021Article
- DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.Molecular biology and evolution · 2021Article
- Conjugation dynamics depend on both the plasmid acquisition cost and the fitness cost.Molecular systems biology · 2021Article
- The Selective Advantage of theFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the absence of antibiotics, it is essential that antibiotic resistance has a fitness cost for microorganisms if suspending antibiotics treatment is to be a useful strategy for reducing antibiotic resistance. However, the cost of antibiotic resistance within the complex ecosystem of the mammalian gut is not well understood. Here, using mice, we show that the same antibiotic resistance mutation can reduce fitness in one host, while being neutral or even increasing fitness in other hosts. Such antagonistic pleiotropy is shaped by the microbiota because resistance in germ-free mice is consistently costly across all hosts, and the host-specific effect on antibiotic resistance is reduced in hosts with similar microbiotas. Using an eco-evolutionary model of competition for resources, we identify a general mechanism that underlies between-host variation and predicts that the dynamics of compensatory evolution of resistant bacteria should be host specific, a prediction that was supported by experimental evolution in vivo. The microbiome of each human is close to unique, and our results suggest that the short-term cost of resistances and their long-term within-host evolution are also highly personalized, a finding that may contribute to the observed variable outcome of withdrawing antibiotics to reduce resistance levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.