Evidence map›Paper›PMID 32632177›Full record

ArticleScientific reports2020

Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes.

N R Harvey, S Voisin, R A Lea, X Yan, M C Benton, I D Papadimitriou, M Jacques, L M Haupt, K J Ashton, N Eynon and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Mitochondrial Genome Variation in Polish Elite Athletes.International journal of molecular sciences · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. The genetics of human performance.Nature reviews. Genetics · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

N R HarveyHealth Sciences and Medicine Faculty, Bond University, Robina, QLD, 4226, Australia.ORCID http://orcid.org/0000-0003-2035-8475
S VoisinInstitute for Health and Sport (IHES), Victoria University, Footscray, VIC, 3011, Australia.ORCID http://orcid.org/0000-0002-4074-7083
R A LeaGenomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
X YanInstitute for Health and Sport (IHES), Victoria University, Footscray, VIC, 3011, Australia.ORCID http://orcid.org/0000-0001-8547-4210
M C BentonGenomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.ORCID http://orcid.org/0000-0003-3442-965X
I D PapadimitriouInstitute for Health and Sport (IHES), Victoria University, Footscray, VIC, 3011, Australia.ORCID http://orcid.org/0000-0001-5032-9937
M JacquesInstitute for Health and Sport (IHES), Victoria University, Footscray, VIC, 3011, Australia.
L M HauptGenomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.ORCID http://orcid.org/0000-0002-7735-8110
K J AshtonHealth Sciences and Medicine Faculty, Bond University, Robina, QLD, 4226, Australia.ORCID http://orcid.org/0000-0001-6106-3425
N Eynon *Institute for Health and Sport (IHES), Victoria University, Footscray, VIC, 3011, Australia.ORCID http://orcid.org/0000-0003-4046-8276
L R Griffiths *Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia. lyn.griffiths@qut.edu.au.ORCID http://orcid.org/0000-0002-6774-5475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria supply intracellular energy requirements during exercise. Specific mitochondrial haplogroups and mitochondrial genetic variants have been associated with athletic performance, and exercise responses. However, these associations were discovered using underpowered, candidate gene approaches, and consequently have not been replicated. Here, we used whole-mitochondrial genome sequencing, in conjunction with high-throughput genotyping arrays, to discover novel genetic variants associated with exercise responses in the Gene SMART (Skeletal Muscle Adaptive Response to Training) cohort (n = 62 completed). We performed a Principal Component Analysis of cohort aerobic fitness measures to build composite traits and test for variants associated with exercise outcomes. None of the mitochondrial genetic variants but eight nuclear encoded variants in seven separate genes were found to be associated with exercise responses (FDR < 0.05) (rs11061368: DIABLO, rs113400963: FAM185A, rs6062129 and rs6121949: MTG2, rs7231304: AFG3L2, rs2041840: NDUFAF7, rs7085433: TIMM23, rs1063271: SPTLC2). Additionally, we outline potential mechanisms by which these variants may be contributing to exercise phenotypes. Our data suggest novel nuclear-encoded SNPs and mitochondrial pathways associated with exercise response phenotypes. Future studies should focus on validating these variants across different cohorts and ethnicities.

Indexed as

ExercisePolymorphism, Single NucleotideAdultAthletic PerformanceCell NucleusCohort StudiesDNA, MitochondrialHigh-Intensity Interval TrainingHumansMitochondriaDNA, Mitochondrial

Identifiers

PMID32632177
PMCPMC7338527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.