ArticleScientific reports2020
Trait and state anxiety are mapped differently in the human brain.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 4 of them syntheses that pooled it.
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Who cites it
136 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Home visits following hospital discharge for families with preterm and low-birthweight infants.The Cochrane database of systematic reviews · 2026Pooled it
- Association between prenatal maternal anxiety and/or stress and offspring's cognitive functioning: A meta-analysis.Child development · 2023Pooled it
- Association between preoperative anxiety and postoperative delirium in older patients: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.Frontiers in public health · 2023Pooled it
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Effect of multimedia education on anxiety and pain in patients undergoing laparoscopic cholecystectomy: a Solomon four-group randomized controlled trial.Scientific reports · 2025Trial
- Effects of visual aid on state anxiety, fear and stress level in patients undergoing endoscopy: a randomized controlled trial.Annals of medicine · 2023Trial
- Improving stress management, anxiety, and mental well-being in medical students through an online Mindfulness-Based Intervention: a randomized study.Scientific reports · 2023Trial
- Exercise Impact on Affective/Cognitive Symptoms and QoL in Subjective Cognitive Decline: An RCT.American journal of Alzheimer's disease and other dementiasTrial
- Trait anxiety selectively amplifies reward learning under uncertainty, while N3 sleep attenuates it.iScience · 2026Article
- Keep calm and exercise on: A single bout of exercise supports executive function across a continuum of trait anxiety levels.Journal of mood and anxiety disorders · 2026Article
- Patterns of Lateral Frontal Delta Asymmetry in Adult Attention-deficit/Hyperactivity Disorder with Comorbid Depression: A Quantitative Electroencephalography Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Exendin-4 alleviates anxiety-like behaviors in chronic restraint stress miceActa pharmaceutica Sinica. B · 2026Article
- MRI Correlates of Depression and Anxiety in Multiple Sclerosis.Diseases (Basel, Switzerland) · 2026Review
- Anxiety, stress, and affective modulation on object-location memory: A systematic review in virtual environments.Cognitive, affective & behavioral neuroscience · 2026Article
- Uncovering the correlation between neurotransmitter-specific functional connectivity and multidimensional anxiety in a non-clinical cohort.European archives of psychiatry and clinical neuroscience · 2026Article
- Multivariate Pattern Analysis Identifies Potential Intertrial Resting-State EEG Biomarkers in Fibromyalgia.The European journal of neuroscience · 2026Article
- Stress, coping, protective factors, and quality of life in parents of infants with CHD: associations with state anxiety.Cardiology in the young · 2026Article
- Momentary anxiety and autonomic responses during everyday social interactions among patients with depression.Translational psychiatry · 2026Article
- Robust Estimation of Polyserial Correlation Coefficients: A Density Power Divergence Approach.Psychometrika · 2026Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety is a mental state characterized by an intense sense of tension, worry or apprehension, relative to something adverse that might happen in the future. Researchers differentiate aspects of anxiety into state and trait, respectively defined as a more transient reaction to an adverse situation, and as a more stable personality attribute in experiencing events. It is yet unclear whether brain structural and functional features may distinguish these aspects of anxiety. To study this, we assessed 42 healthy participants with the State-Trait Anxiety Inventory and then investigated with MRI to characterize structural grey matter covariance and resting-state functional connectivity (rs-FC). We found several differences in the structural-functional patterns across anxiety types: (1) trait anxiety was associated to both structural covariance of Default Mode Network (DMN), with an increase in dorsal nodes and a decrease in its ventral part, and to rs-FC of DMN within frontal regions; (2) state anxiety, instead, was widely related to rs-FC of Salience Network and of DMN, specifically in its ventral nodes, but not associated with any structural pattern. In conclusion, our study provides evidence of a neuroanatomical and functional distinction between state and trait anxiety. These neural features may be additional markers in future studies evaluating early diagnosis or treatment effects.
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