Evidence map›Paper›PMID 32632152›Full record

ArticleScientific reports2020

A novel diterpene agent isolated from Microbispora hainanensis strain CSR-4 and its in vitro and in silico inhibition effects on acetylcholine esterase enzyme.

Chitti Thawai, Nantiya Bunbamrung, Pattama Pittayakhajonwut, Sumet Chongruchiroj, Jaturong Pratuangdejkul, Ya-Wen He, Sarin Tadtong, Vipaporn Sareedenchai, Pinidphon Prombutara, Yang Qian

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The Underexplored GenusMarine drugs · 2026
    Review
  2. The Diels-Alder Reaction as a Key Step in Natural Product Synthesis.Progress in the chemistry of organic natural products · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chitti ThawaiDepartment of Biology, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand. chitti.th@kmitl.ac.th.
Nantiya BunbamrungNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, 12120, Pathum Thani, Thailand.
Pattama PittayakhajonwutNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, 12120, Pathum Thani, Thailand.
Sumet ChongruchirojDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Phayathai, Bangkok, 10400, Thailand.
Jaturong PratuangdejkulDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Phayathai, Bangkok, 10400, Thailand.
Ya-Wen HeState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Sarin TadtongDepartment of Pharmacognosy, Faculty of Pharmacy, Srinakharinwirot University, Ongkarak, 26120, Nakhon nayok, Thailand.
Vipaporn SareedenchaiDepartment of Pharmacognosy, Faculty of Pharmacy, Srinakharinwirot University, Ongkarak, 26120, Nakhon nayok, Thailand.
Pinidphon PrombutaraOmics Sciences and Bioinformatics Center, Faculty of Science, Chulalongkorn University, 254 Payathai Road, Patumwan, Bangkok, 10330, Thailand.
Yang QianDepartment of Life Science and Engineering, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An actinomycete strain CSR-4 was isolated from the rhizosphere soil of Zingiber montanum. Taxonomic characterization revealed strain CSR-4 was a member of the genus Microbispora. Whole-genome sequence analysis exhibited the highest average nucleotide identity (ANI) value (95.34%) and digital DNA-DNA hybridization (DDH) value (74.7%) between strain CSR-4 and the closest relative M. hainanensis DSM 45428

Indexed as

AcetylcholinesteraseActinobacteriaAnimalsAntioxidantsCatalytic DomainChlorocebus aethiopsCholinesterase InhibitorsComputer SimulationDiterpenesHumansIn Vitro TechniquesMiceMolecular Dynamics SimulationMolecular StructureNeuroprotective AgentsPhylogenyAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsDiterpenesNeuroprotective AgentsRecombinant ProteinsRNA, Ribosomal, 16S

Identifiers

PMID32632152
PMCPMC7338456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.