ArticleScientific reports2020
Impact of histological diagnosis on the treatment of atypical brainstem lesions.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Stereotactic Biopsy for Brainstem Lesions: A Meta-analysis with Noncomparative Binary Data.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Intraoperative tract mapping through the biopsy cannula during stereotactic biopsy of brainstem lesions: a prospective feasibility study.Journal of neuro-oncology · 2026Article
- Exploration of the prognostic value of the resection of adult brainstem high-grade glioma based on competing risk model, propensity score matching, and conditional survival rate.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Biopsy-proven Primary CNS Lymphoma in the Medulla Oblongata Presenting as Anorexia.NMC case report journal · 2023Article
- Article
- Use of intra-operative stimulation of brainstem lesion target sites for frameless stereotactic biopsies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- 5-aminolevulinic acid-guided surgery for focal pediatric brainstem gliomas: A preliminary study.Surgical neurology international · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For atypical brainstem lesions, histological diagnosis can have an impact on treatment, especially in cases where diffuse glioma is not found. Since radiotherapy is the only therapeutic modality that has shown clinical and radiographic improvement in patients with diffuse glioma, the misdiagnosis of diffuse glioma can have drastic consequences, particularly in patients with nontumorous lesions. Thus, the purpose of this study was to evaluate the impact of histological diagnosis on the treatment of atypical brainstem lesions. This was a retrospective study of 31 patients who underwent biopsy of atypical brainstem lesions. The procedures were performed between January 2008 and December 2018 at the Life Center Hospital and Santa Casa de Belo Horizonte, MG, Brazil. A diagnosis was obtained in 26 (83.9%) cases. Three patients presented complications: one presented bleeding with no clinical repercussions and two showed worsening of neurological deficit, only one of which was definitive. No mortality occurred due to the procedure. The histological diagnosis was diffuse glioma in seven cases (22.6%) and not diffuse glioma in 19 cases (61.3%). Thus, the histological diagnosis had an impact on the treatment of 19 patients (treatment impact rate: 61.3%). The histological diagnosis of intrinsic brainstem lesions is a safe, efficient procedure with a high diagnosis rate, and as such, it should be considered in the management of atypical lesions.
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