ArticleProceedings of the National Academy of Sciences of the United States of America2020
Functionally distinct Purkinje cell types show temporal precision in encoding locomotion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- The cerebellum implements structured representation of valence to support adaptive behavior control.Science advances · 2026Article
- A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Ultrastructural Characteristics of the Juvenile Chum Salmon (International journal of molecular sciences · 2025Article
- Article
- Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024Review
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Heterogeneous encoding of temporal stimuli in the cerebellar cortex.Nature communications · 2023Article
- Mechanosensory signal transmission in the arms and the nerve ring, an interarm connective, ofiScience · 2023Article
- Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish.eLife · 2023Article
- A Critical Review of Zebrafish Neurological Disease Models-2. Application: Functional and Neuroanatomical Phenotyping Strategies and Chemical Screens.Oxford open neuroscience · 2023Article
- Neuronal and non-neuronal scaling across brain regions within an intercross of domestic and wild chickens.Frontiers in neuroanatomy · 2022Article
- A quantitative analysis of cerebellar anatomy in birds.Brain structure & function · 2021Article
- The cerebellar anatomy of red junglefowl and white leghorn chickens: insights into the effects of domestication on the cerebellum.Royal Society open science · 2021Article
- Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses.Scientific reports · 2021Article
- Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord.Nature communications · 2021Article
- Projection-dependent heterogeneity of cerebellar granule cell calcium responses.Molecular brain · 2021Article
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice.Avicenna journal of phytomedicineArticle
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. Here, we show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. Dual patch-clamp recordings showed that the cerebellar circuit contains all Purkinje cell types that cross-communicate extensively using chemical and electrical synapses. Further activation of spinal central pattern generators (CPGs) revealed unique phase-locked activity from each Purkinje cell type during the locomotor cycle. Thus, we show intricately organized Purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions.
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