Evidence map›Paper›PMID 32632007›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Label-free optical detection of bioelectric potentials using electrochromic thin films.

Felix S Alfonso, Yuecheng Zhou, Erica Liu, Allister F McGuire, Yang Yang, Husniye Kantarci, Dong Li, Eric Copenhaver, J Bradley Zuchero, Holger Müller and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

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  18. Nanotechnology Enables Novel Modalities for Neuromodulation.Advanced materials (Deerfield Beach, Fla.) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Felix S AlfonsoDepartment of Chemistry, Stanford University, Stanford, CA 94305.ORCID 0000-0001-7765-1256
Yuecheng ZhouDepartment of Chemistry, Stanford University, Stanford, CA 94305.ORCID 0000-0002-3105-7697
Erica LiuDepartment of Chemistry, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1193-0049
Allister F McGuireDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Yang YangDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Husniye KantarciDepartment of Neurosurgery, Stanford University, Stanford, CA 94305.ORCID 0000-0002-3667-8003
Dong LiDepartment of Neurosurgery, Stanford University, Stanford, CA 94305.
Eric CopenhaverDepartment of Physics, University of California, Berkeley, CA 94720.
J Bradley ZucheroDepartment of Neurosurgery, Stanford University, Stanford, CA 94305.ORCID 0000-0002-4706-2538
Holger MüllerDepartment of Physics, University of California, Berkeley, CA 94720; bcui@stanford.edu hm@berkeley.edu.ORCID 0000-0003-0636-5951
Bianxiao CuiDepartment of Chemistry, Stanford University, Stanford, CA 94305; bcui@stanford.edu hm@berkeley.edu.ORCID 0000-0002-8044-5629
Stanford University · USLawrence Berkeley National Laboratory · US

Funding

Developing nanoscale electrophysiology sensors for robust intracellular recordingR01GM125737 · NIGMS · STANFORD UNIVERSITY · PI CUI, BIANXIAO · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM125737
6 · The paper itself

Abstract

Understanding how a network of interconnected neurons receives, stores, and processes information in the human brain is one of the outstanding scientific challenges of our time. The ability to reliably detect neuroelectric activities is essential to addressing this challenge. Optical recording using voltage-sensitive fluorescent probes has provided unprecedented flexibility for choosing regions of interest in recording neuronal activities. However, when recording at a high frame rate such as 500 to 1,000 Hz, fluorescence-based voltage sensors often suffer from photobleaching and phototoxicity, which limit the recording duration. Here, we report an approach called electrochromic optical recording (ECORE) that achieves label-free optical recording of spontaneous neuroelectrical activities. ECORE utilizes the electrochromism of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) thin films, whose optical absorption can be modulated by an applied voltage. Being based on optical reflection instead of fluorescence, ECORE offers the flexibility of an optical probe without suffering from photobleaching or phototoxicity. Using ECORE, we optically recorded spontaneous action potentials in cardiomyocytes, cultured hippocampal and dorsal root ganglion neurons, and brain slices. With minimal perturbation to cells, ECORE allows long-term optical recording over multiple days.

Indexed as

PolystyrenesThiophenesAction PotentialsBrainElectrochemical TechniquesElectrophysiological PhenomenaElectrophysiologyFluorescent DyesGanglia, SpinalHumansNeuronsOptical ImagingOptics and PhotonicsFluorescent Dyespoly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)Polystyrenespolystyrene sulfonic acidThiophenesaction potentialelectrochromicneuronsoptical electrophysiologyPEDOT:PSS

Identifiers

PMID32632007
PMCPMC7382226
OpenAlexW3041439784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.