ArticleProceedings of the National Academy of Sciences of the United States of America2020
Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Similar Response Dynamics Represent Opposite Behaviors and Rewards in the Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling.Cell discovery · 2026Article
- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- Short-term memory errors are strongly associated with a drift in neural activity in the posterior parietal cortex.PLoS biology · 2025Article
- Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.Nature communications · 2025Article
- Similar Dynamic Frontal Cortex Representations of Auditory Stimuli Cueing Opposite Actions and Rewards.bioRxiv : the preprint server for biology · 2025Article
- Transdiagnostic neuromodulation of impulsivity: current status and future trajectories.Translational psychiatry · 2025Review
- Whether or not to act is determined by distinct signals from motor thalamus and orbitofrontal cortex to secondary motor cortex.Nature communications · 2025Article
- Article
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
- Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2024Review
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- DSP-6745, a novel 5-hydroxytryptamine modulator with rapid antidepressant, anxiolytic, antipsychotic and procognitive effects.Psychopharmacology · 2024Article
- Movement-related increases in subthalamic activity optimize locomotion.Cell reports · 2024Article
- The Switchmaze: an open-design device for measuring motivation and drive switching in mice.Peer community journal · 2024Article
- Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice.eLife · 2024Article
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Behavioral measurements of motor readiness in mice.Current biology : CB · 2023Article
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4 authors.
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Abstract
The prefrontal cortex (PFC) plays a critical role in curbing impulsive behavior, but the underlying circuit mechanism remains incompletely understood. Here we show that a subset of dorsomedial PFC (dmPFC) layer 5 pyramidal neurons, which project to the subthalamic nucleus (STN) of the basal ganglia, play a key role in inhibiting impulsive responses in a go/no-go task. Projection-specific labeling and calcium imaging showed that the great majority of STN-projecting neurons were preferentially active in no-go trials when the mouse successfully withheld licking responses, but lateral hypothalamus (LH)-projecting neurons were more active in go trials with licking; visual cortex (V1)-projecting neurons showed only weak task-related activity. Optogenetic activation and inactivation of STN-projecting neurons reduced and increased inappropriate licking, respectively, partly through their direct innervation of the STN, but manipulating LH-projecting neurons had the opposite effects. These results identify a projection-defined subtype of PFC pyramidal neurons as key mediators of impulse control.
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