Evidence map›Paper›PMID 32631991›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Noninvasive acoustic manipulation of objects in a living body.

Mohamed A Ghanem, Adam D Maxwell, Yak-Nam Wang, Bryan W Cunitz, Vera A Khokhlova, Oleg A Sapozhnikov, Michael R Bailey

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
  2. Article
  3. The 2026 guided acoustic waves roadmap.Journal of physics D: Applied physics · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Treatment Planning and Aberration Correction Algorithm for HIFU Ablation of Renal Tumors.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mohamed A GhanemCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105; mghanem@uw.edu.
Adam D MaxwellCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105.
Yak-Nam WangCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105.
Bryan W CunitzCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105.
Vera A KhokhlovaCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105.
Oleg A SapozhnikovCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105.
Michael R BaileyCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105.ORCID 0000-0003-0491-6465
University of Washington Applied Physics Laboratory · USLomonosov Moscow State University · RUUniversity of Washington · US

Funding

SWL AND RENAL INJURY AND STONE COMMINUTIONP01DK043881 · NIDDK · UNIVERSITY OF WASHINGTON · PI BAILEY, MICHAEL R · 1994 to 2023
$33.5M
Nonlinear Acoustics in Calibration/Metrology of High Intensity Focused UltrasoundR01EB007643 · NIBIB · UNIVERSITY OF WASHINGTON · PI KHOKHLOVA, VERA · 2008 to 2020
$6.9M
Noninvasive fragmentation of urinary calculi with focused ultrasound burstsK01DK104854 · NIDDK · UNIVERSITY OF WASHINGTON · PI MAXWELL, ADAM DOUGLAS · 2015 to 2019
$686k
NIBIB NIH HHS R01 EB007643NIDDK NIH HHS K01 DK104854NIDDK NIH HHS P01 DK043881
6 · The paper itself

Abstract

In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogrammed paths, in a water bath, and in the urinary bladders of live pigs. Deviation from the intended path was on average <10%. No injury was found on the bladder wall or intervening tissue.

Indexed as

Ultrasonic WavesAnimalsKidney CalculiSwineTransducersUltrasonic Therapyacoustic radiation forceacoustic tweezerskidney stones

Identifiers

PMID32631991
PMCPMC7382215
OpenAlexW3040480361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.