Evidence map›Paper›PMID 32631953›Full record

ArticleThe Journal of biological chemistry2020

Axenfeld-Rieger syndrome-associated mutants of the transcription factor FOXC1 abnormally regulate

Qinxin Zhang, Dong Liang, Yunyun Yue, Luqingqing He, Nan Li, Dongya Jiang, Ping Hu, Qingshun Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Mechanistic Insights into Axenfeld-Rieger Syndrome from ZebrafishInternational journal of molecular sciences · 2021
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qinxin ZhangMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.ORCID 0000-0003-3819-5504
Dong LiangDepartment of Prenatal Diagnosis, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China qingshun@nju.edu.cn liangdong@njmu.edu.cn.
Yunyun YueSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Luqingqing HeMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Nan LiMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Dongya JiangMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
Ping HuDepartment of Prenatal Diagnosis, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
Qingshun ZhaoMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China qingshun@nju.edu.cn liangdong@njmu.edu.cn.ORCID 0000-0001-9536-4672
Model Animal Research Center · CNNanjing Maternity and Child Health Care Hospital · CNChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOXC1 is a member of the forkhead family of transcription factors, and whose function is poorly understood. A variety of

Indexed as

MutationAnimalsAnterior Eye SegmentCell LineDisease Models, AnimalEye AbnormalitiesEye Diseases, HereditaryForkhead Transcription FactorsGene Expression Regulation, DevelopmentalHEK293 CellsHomeobox Protein Nkx-2.5HumansZebrafishForkhead Transcription FactorsFOXC1 protein, humanHomeobox Protein Nkx-2.5NKX2-5 protein, humanAxenfeld-Rieger syndromecardiovascular disease：congenital heart diseasesFOXC1H9c2heartmutantNKX2-5transcription factorzebrafish

Identifiers

PMID32631953
PMCPMC7450120
OpenAlexW3038158277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.