Evidence map›Paper›PMID 32631949›Full record

ArticleG3 (Bethesda, Md.)2020

Loss of the Antimicrobial Peptide Metchnikowin Protects Against Traumatic Brain Injury Outcomes in

Laura C Swanson, Stacey A Rimkus, Barry Ganetzky, David A Wassarman

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Proline-Rich Antimicrobial Peptides from Invertebrates.Molecules (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Review
  12. Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laura C SwansonDepartment of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-9438-7546
Stacey A RimkusDepartment of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Barry GanetzkyDepartment of Genetics, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0001-5418-7577
David A WassarmanDepartment of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706 dawassarman@wisc.edu.ORCID 0000-0002-7042-9561
University of Wisconsin–Madison · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
TBI and aging in a Drosophila modelRF1NS114359 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, DAVID · 2019 to 2019
$2.8M
NIA NIH HHS T32 AG000213NIGMS NIH HHS T32 GM008692NINDS NIH HHS RF1 NS114359
6 · The paper itself

Abstract

Neuroinflammation is a major pathophysiological feature of traumatic brain injury (TBI). Early and persistent activation of innate immune response signaling pathways by primary injuries is associated with secondary cellular injuries that cause TBI outcomes to change over time. We used a

Indexed as

Brain Injuries, TraumaticDrosophila ProteinsAnimalsAntimicrobial Cationic PeptidesDrosophila melanogasterPore Forming Cytotoxic ProteinsAntimicrobial Cationic PeptidesDrosophila ProteinsPore Forming Cytotoxic Proteinsantimicrobial peptideDrosophila melanogasterinnate immune responseMetchnikowintraumatic brain injury

Identifiers

PMID32631949
PMCPMC7466987
OpenAlexW3040788213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.