ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Pupillary Dynamics Link Spontaneous and Task-Evoked Activations Recorded Directly from Human Insula.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 51 citations in OpenAlex.
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- Real-time fMRI-triggered experience-sampling: a proof-of-concept study.bioRxiv : the preprint server for biology · 2026Article
- Brain-Pupil Coupling Revealed Through Deep Learning of Intracranial Recordings.Human brain mapping · 2025Article
- Neural Sensitivity to the Heartbeat Is Modulated by Fluctuations in Affective Arousal during Spontaneous Thought.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Direct interactions between the human insula and hippocampus during memory encoding.Nature neuroscience · 2025Article
- Neural sensitivity to the heartbeat is modulated by fluctuations in affective arousal during spontaneous thought.bioRxiv : the preprint server for biology · 2025Article
- Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG.Brain sciences · 2025Article
- Locus coeruleus-related insula activation supports implicit learning.bioRxiv : the preprint server for biology · 2025Article
- The brain's action-mode network.Nature reviews. Neuroscience · 2025Review
- Spontaneous slow cortical potentials and brain oscillations independently influence conscious visual perception.PLoS biology · 2025Article
- Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex.Scientific reports · 2024Article
- Network mechanisms of ongoing brain activity's influence on conscious visual perception.Nature communications · 2024Article
- Recent advances in the neuroscience of spontaneous and off-task thought: implications for mental health.Nature. Mental health · 2023Article
- Why is everyone talking about brain state?Trends in neurosciences · 2023Review
- Pupillary response is associated with the reset and switching of functional brain networks during salience processing.PLoS computational biology · 2023Article
- A tripartite view of the posterior cingulate cortex.Nature reviews. Neuroscience · 2023Review
- Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study.Molecular autism · 2023Article
- Dynamic interactions between anterior insula and anterior cingulate cortex link perceptual features and heart rate variability during movie viewing.Network neuroscience (Cambridge, Mass.) · 2023Article
- An insula hierarchical network architecture for active interoceptive inference.Royal Society open science · 2022Review
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2 authors at 2 institutions in 1 country.
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Abstract
Spontaneous activations within neuronal populations can emerge similarly to "task-evoked" activations elicited during cognitive performance or sensory stimulation. We hypothesized that spontaneous activations within a given brain region have comparable functional and physiological properties to task-evoked activations. Using human intracranial EEG with concurrent pupillometry in 3 subjects (2 males, 1 female), we localized neuronal populations in the dorsal anterior insular cortex that showed task-evoked activations correlating positively with the magnitude of pupil dilation during a continuous performance task. The pupillary response peaks lagged behind insular activations by several hundreds of milliseconds. We then detected spontaneous activations, within the same neuronal populations of insular cortex, that emerged intermittently during a wakeful "resting state" and that had comparable electrophysiological properties (magnitude, duration, and spectral signature) to task-evoked activations. Critically, similar to task-evoked activations, spontaneous activations systematically preceded phasic pupil dilations with a strikingly similar temporal profile. Our findings suggest similar neurophysiological profiles between spontaneous and task-evoked activations in the human insula and support a clear link between these activations and autonomic functions measured by dynamics of pupillary dilation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.