Evidence map›Paper›PMID 32631917›Full record

ArticleInfection and immunity2020

Aggregative Adherence Fimbriae II of Enteroaggregative Escherichia coli Are Required for Adherence and Barrier Disruption during Infection of Human Colonoids.

Laura A Gonyar, Rachel M Smith, Jorge A Giron, Nicholas C Zachos, Fernando Ruiz-Perez, James P Nataro

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Deciphering the Implications ofPathogens (Basel, Switzerland) · 2026
    Review
  3. EnteroaggregativeEcoSal Plus · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Antimicrobial ResistantPathogens (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. A Novel Adult Murine Model of Typical EnteroaggregativeFrontiers in cellular and infection microbiology · 2022
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laura A GonyarDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA lap5b@virginia.edu.ORCID 0000-0001-5380-4254
Rachel M SmithDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Jorge A GironDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Nicholas C ZachosDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, USA.
Fernando Ruiz-PerezDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
James P NataroDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USJohns Hopkins University · US

Funding

Project 3 - Human colonoids as a model for the pathobiology of EHECP01AI125181 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RUIZ, FERNANDO · 2016 to 2025
$18.6M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
NIAID NIH HHS P01 AI125181NIDDK NIH HHS P30 DK089502
6 · The paper itself

Abstract

Symptomatic and asymptomatic infection with the diarrheal pathogen enteroaggregative

Indexed as

Adhesins, Escherichia coliBacterial AdhesionColonColony Count, MicrobialDuodenumEpithelial CellsEscherichia coliEscherichia coli InfectionsFimbriae, BacterialGene DeletionGene Expression RegulationGenetic Complementation TestHost Microbial InteractionsHumansIntestinal MucosaMucin-2Adhesins, Escherichia coliMUC2 protein, humanMucin-2adherenceaggregativebarrier disruptioncolonoidEscherichia colifimbriaeorganoid

Identifiers

PMID32631917
PMCPMC7440768
OpenAlexW3038568831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.