Evidence map›Paper›PMID 32631903›Full record

ArticleMolecular and cellular biology2020

Janus Kinase Mutations in Mice Lacking PU.1 and Spi-B Drive B Cell Leukemia through Reactive Oxygen Species-Induced DNA Damage.

Michelle Lim, Carolina R Batista, Bruno R de Oliveira, Rachel Creighton, Jacob Ferguson, Kurt Clemmer, Devon Knight, James Iansavitchous, Danish Mahmood, Mariano Avino and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Michelle LimDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Carolina R BatistaDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Bruno R de OliveiraDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Rachel CreightonDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Jacob FergusonDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Kurt ClemmerDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Devon KnightDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
James IansavitchousDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Danish MahmoodDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Mariano AvinoDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Rodney P DeKoterDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada rdekoter@uwo.ca.ORCID 0000-0002-9201-1983
Western University · CA

Funding

CIHR 142250
6 · The paper itself

Abstract

Precursor B cell acute lymphoblastic leukemia (B-ALL) is caused by genetic lesions in developing B cells that function as drivers for the accumulation of additional mutations in an evolutionary selection process. We investigated secondary drivers of leukemogenesis in a mouse model of B-ALL driven by PU.1/Spi-B deletion (Mb1-CreΔPB). Whole-exome-sequencing analysis revealed recurrent mutations in

Indexed as

DNA DamageAnimalsB-LymphocytesCell Line, TumorCell ProliferationHumansJanus Kinase 1Janus Kinase 3Leukemia, B-CellMaleMiceMice, Inbred C57BLMice, KnockoutMutationPrecursor Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene ProteinsJAK1 protein, humanJAK3 protein, humanJanus Kinase 1Janus Kinase 3Proto-Oncogene ProteinsProto-Oncogene Proteins c-etsProto-Oncogene Protein Spi-1Reactive Oxygen SpeciesSpi-B protein, mouseTrans-ActivatorsETS transcription factorsgene regulationleukemiaPU.1reactive oxygen speciesSpi-Btranscription factors

Identifiers

PMID32631903
PMCPMC7459267
OpenAlexW3038478510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.