Evidence map›Paper›PMID 32631827›Full record

ArticleAntimicrobial agents and chemotherapy2020

CRISPR-Cas9-Mediated Carbapenemase Gene and Plasmid Curing in Carbapenem-Resistant

Mingju Hao, Yuzhang He, Haifang Zhang, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun, Hong Du, Barry N Kreiswirth, Liang Chen

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Plasmid encodedBiofilm · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Advances in CRISPR-Cas for Diagnosis and Treatment ofPathogens (Basel, Switzerland) · 2026
    Review
  9. Article
  10. Genetic basis of cefiderocol resistance inMicrobiology spectrum · 2026
    Article
  11. Review
  12. Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Emergence ofbioRxiv : the preprint server for biology · 2025
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Mingju Hao *Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.
Yuzhang He *National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.
Haifang Zhang *Department of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiao-Ping LiaoNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.
Ya-Hong LiuNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.
Jian SunNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.ORCID 0000-0002-4209-7555
Hong DuDepartment of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack-Meridian Health, Nutley, New Jersey, USA.
Liang ChenCenter for Discovery and Innovation, Hackensack-Meridian Health, Nutley, New Jersey, USA liang.chen@hmh-cdi.org.ORCID 0000-0001-5845-2235
South China Agricultural University · CNHackensack Meridian Health · USSoochow University · CNShandong First Medical University · CN

Funding

The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
NIAID NIH HHS R01 AI090155
6 · The paper itself

Abstract

Combating plasmid-mediated carbapenem resistance is essential to control and prevent the dissemination of carbapenem-resistant

Indexed as

Carbapenem-Resistant EnterobacteriaceaeEnterobacteriaceae InfectionsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCRISPR-Cas SystemsEnterobacterMicrobial Sensitivity TestsPlasmidsAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasescarbapenemaseantimicrobial resistancecarbapenem-resistant EnterobacteriaceaeCRISPR-Casplasmid

Identifiers

PMID32631827
PMCPMC7449206
OpenAlexW3038989986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.