Evidence map›Paper›PMID 32631825›Full record

ArticleAntimicrobial agents and chemotherapy2020

Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance.

Catherine Vilchèze, Rajagopalan Saranathan, Brian Weinrick, William R Jacobs

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catherine VilchèzeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Rajagopalan SaranathanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Brian WeinrickDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0003-0880-4487
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA william.jacobs@einsteinmed.org.ORCID 0000-0003-3321-3080

Funding

Validation and Application of a Model for Human-like TB Latency in RabbitsU19AI111276 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, HORN, DAVID LOUIS · 2014 to 2020
$23.3M
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
NIAID NIH HHS R01 AI026170NIAID NIH HHS R37 AI026170NIAID NIH HHS U19 AI111276
6 · The paper itself

Abstract

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant

Indexed as

IsoniazidMycobacterium tuberculosisAntitubercular AgentsBacterial ProteinsCatalaseDrug Resistance, BacterialMutationAntitubercular AgentsBacterial ProteinsCatalaseIsoniazidargininedeletionisoniazidresistance

Identifiers

PMID32631825
PMCPMC7449219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.