Evidence map›Paper›PMID 32631701›Full record

ArticleSchizophrenia research2020

Schizotypal traits and neuropsychological performance: The role of processing speed.

James Gilleen, Marcello Tesse, Tjasa Velikonja, Mark Weiser, Michael Davidson, Abraham Reichenberg

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

James GilleenDepartment of Psychology, University of Roehampton, London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: james.gilleen@roehampton.ac.uk.
Marcello TesseDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tjasa VelikonjaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Mark WeiserDepartment of Psychiatry, Sheba Medical Centre, Tel Hashomer, Israel.
Michael DavidsonDepartment of Psychiatry, Sheba Medical Centre, Tel Hashomer, Israel.
Abraham ReichenbergDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
King's College London · GBSheba Medical Center · ILIcahn School of Medicine at Mount Sinai · US

Funding

Schizophrenia Premorbid EndophenotypeR01MH066105 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI DAVIDSON, MICHAEL · 2004 to 2008
$1.7M
NIMH NIH HHS R01 MH066105
6 · The paper itself

Abstract

backgroundCognitive deficits, particularly in processing speed, are widely recognized as a critical feature of schizophrenia, and are also present across schizophrenia spectrum disorders. A number of important confounders, however, such as hospitalization effects and antipsychotic medication, have been shown to affect processing speed, causing debate as to the core cognitive deficits of schizophrenia. The study of individuals who are not clinically psychotic but have schizotypal traits allows investigation of cognitive deficits associated with both positive and negative schizotypy dimensions while excluding potential confounds.

methodsA population-based community sample of 242 healthy adult volunteers assessed using the Structured Interview of Schizotypy - Revised (SIS-R) scale, and a neuropsychological testing battery that included measures of verbal ability, visual and verbal memory, verbal fluency, working memory, executive functions and processing speed. Participants were classified in High or Low Positive Schizotypy (H-PST or L-PST), High or Low Paranoia-like traits (H-PAR or L-PAR) and High or Low Negative Schizotypy (H-NST or L-NST) groups, respectively.

resultsIndividuals with H-PST performed significantly (p < 0.05) worse than L-PST on measures of processing speed and executive functions. Processing speed deficits were also observed in individuals with H-PAR compared to L-PAR (p < 0.05). There were no statistically significant differences in neuropsychological performance between H-NST and L-NST on any measure.

conclusionsIn a population-based community sample, individuals with high positive schizotypal traits or paranoia-like traits show impairments in processing speed. Consistent with a dimensional view of psychosis, this supports the hypothesis that processing speed represents a core deficit of schizophrenia-like mental states.

Indexed as

Cognition DisordersPsychotic DisordersSchizotypal Personality DisorderAdultCognitionHumansNeuropsychological TestsExecutive functionsNeurocognitionProcessing speedSchizophreniaSchizotypy

Identifiers

PMID32631701
PMCPMC7704687
OpenAlexW3039646215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.