Evidence map›Paper›PMID 32631561›Full record

ArticleBioorganic & medicinal chemistry2020

Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT

Anupam Karki, Hari K Namballa, Ian Alberts, Wayne W Harding

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Synthesis and evaluation of aporphinoid 5-HTBioorganic & medicinal chemistry letters · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anupam KarkiDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA; Program in Biochemistry, CUNY Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA.
Hari K NamballaDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA.
Ian AlbertsLaGuardia Community College, Department of Chemistry, 31-10 Thompson Avenue, LIC, NY 11104, USA.
Wayne W HardingDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA; Program in Biochemistry, CUNY Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA; Program in Chemistry, CUNY Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA. Electronic address: whardi@hunter.cuny.edu.
City University of New York · USLaGuardia Community College · US

Funding

Novel anti-cocaine D1 partial agonistsSC1DA049961 · NIDA · HUNTER COLLEGE · PI HARDING, WAYNE WESLEY · 2019 to 2022
$1.6M
NIDA NIH HHS SC1 DA049961
6 · The paper itself

Abstract

Aporphine alkaloids containing a C10 nitrogen motif were synthesized and evaluated for affinity at 5-HT

Indexed as

AporphinesCell LineHumansLigandsMolecular Docking SimulationMolecular StructureReceptors, SerotoninSerotonin AntagonistsStructure-Activity RelationshipAporphinesLigandsReceptors, Serotoninserotonin 7 receptorSerotonin Antagonists5-HT(1A)5-HT(7)AporphineCNSDopamineSARSerotonin

Identifiers

PMID32631561
PMCPMC7340851
OpenAlexW3033960375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.