ArticleParasites & vectors2020
Lipid composition and abundance in the reproductive and alimentary tracts of female Haemonchus contortus.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- The temporal characteristics of pharyngeal microbiota and plasma lipidomics by silica exposure in coal miner.Scientific reports · 2025Article
- The Lipid Composition of the Exo-Metabolome fromMetabolites · 2025Article
- The developmental lipidome of Nippostrongylus brasiliensis.Parasites & vectors · 2025Article
- The Mitogenome of the Haecon-5 Strain ofInternational journal of molecular sciences · 2024Article
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2023Article
- The Proteome and Lipidome of Extracellular Vesicles fromInternational journal of molecular sciences · 2023Article
- Broad-Spectrum Inhibitors for Conserved Unique Phosphoethanolamine Methyltransferases in Parasitic Nematodes Possess Anthelmintic Efficacy.Antimicrobial agents and chemotherapy · 2023Article
- An informatic workflow for the enhanced annotation of excretory/secretory proteins ofComputational and structural biotechnology journal · 2023Article
- Thermal proteome profiling revealsFrontiers in pharmacology · 2022Article
- Helminth lipidomics: Technical aspects and future prospects.Current research in parasitology & vector-borne diseases · 2021Review
- Quantitative lipidomic analysis of Ascaris suum.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipids play essential structural and functional roles in the biology of animals. Studying the composition and abundance of lipids in parasites should assist in gaining a better understanding of their molecular biology, biochemistry and host-parasite interactions.
methodsHere, we used a combination of high-performance liquid chromatography and mass spectrometric analyses, combined with bioinformatics, to explore the lipid composition and abundance in the reproductive (Rt) and alimentary (At) tracts of Haemonchus contortus.
resultsWe identified and quantified 320 unique lipid species representing four categories: glycerolipids, glycerophospholipids, sphingolipids and steroid lipids. Glycerolipids (i.e. triradylglycerols) and glycerophospholipids (i.e. glycerophosphocholines) were the most commonly and abundant lipid classes identified and were significantly enriched in Rt and At, respectively. We propose that select parasite-derived lipids in Rt and At of adult female H. contortus are required as an energy source (i.e. triradylglycerol) or are involved in phospholipid biosynthesis (i.e. incorporated fatty acids) and host-parasite interactions (i.e. phospholipids and lysophospholipids).
conclusionsThis work provides a first foundation to explore lipids at the organ-specific and tissue-specific levels in nematodes, and to start to unravel aspects of lipid transport, synthesis and metabolism, with a perspective on discovering new intervention targets.
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