Evidence map›Paper›PMID 32631374›Full record

ArticleBMC medical genomics2020

Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration.

Andrea R Waksmunski, Michelle Grunin, Tyler G Kinzy, Robert P Igo, Jonathan L Haines, Jessica N Cooke Bailey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea R WaksmunskiDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Michelle GruninCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Tyler G KinzyDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Robert P IgoDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Jonathan L HainesDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Jessica N Cooke BaileyCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA. jnc43@case.edu.ORCID 0000-0002-4001-8702

Funding

Institutional Career Development CoreKL2TR002547 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI DWEIK, RAED A. · 2018 to 2022
$7.7M
VISUAL SCIENCES TRAINING PROGRAMT32EY007157 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Johannes Friedrich von Lintig · 2000 to 2026
$5.5M
International Advancing genomics through the AMD Genomics Consortium (IAMDGC)R01EY022310 · NEI · VANDERBILT UNIVERSITY · PI BLANTON, SUSAN HALLORAN, HAINES, JONATHAN L · 2012 to 2024
$4.9M
NCATS NIH HHS KL2 TR002547NEI NIH HHS 1X01HG006934-01NEI NIH HHS R01 EY022310NEI NIH HHS T32 EY007157
6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD) is a progressive retinal disease contributing to blindness worldwide. Multiple estimates for AMD heritability (h

methodsWe performed genomic-relatedness-based restricted maximum-likelihood (GREML) analyses on ADV, geographic atrophy (GA), and choroidal neovascularization (CNV) subtypes to investigate the h

resultsVia GREML, full chip h

conclusionsPathway analyses, which leverage biological relationships among genes in a pathway, may be useful in identifying additional loci that contribute to the heritability of complex disorders in a non-additive manner. Heritability analyses of these loci, especially amongst disease subtypes, may provide clues to the importance of specific genes to the genetic architecture of AMD.

Indexed as

Genetic MarkersGenetic Predisposition to DiseasePolymorphism, Single NucleotideSoftwareFemaleGenome-Wide Association StudyHumansMacular DegenerationMaleMiddle AgedRisk FactorsGenetic MarkersGenome-wide association studyGREMLHeritabilityPathway analysisStatistical driver gene

Identifiers

PMID32631374
PMCPMC7336430

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.