Evidence map›Paper›PMID 32631331›Full record

ArticleBMC infectious diseases2020

Gastrointestinal symptoms in invasive pneumococcal disease: a cohort study.

Hans Kristian Floeystad, Jacob Dag Berild, Bjoern Jardar Brandsaeter, Didrik Frimann Vestrheim, Dag Berild, Are Martin Holm

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hans Kristian FloeystadDepartment of Internal Medicine, Sorlandet Hospital, Kristiansand, Norway. hafloe@sshf.no.
Jacob Dag BerildNorwegian Institute of Public Health, Division of infection control and environmental health, Oslo, Norway.
Bjoern Jardar BrandsaeterDepartment of Internal Medicine, Lovisenberg Hospital, Oslo, Norway.
Didrik Frimann VestrheimNorwegian Institute of Public Health, Division of infection control and environmental health, Oslo, Norway.
Dag BerildDepartment of Infectious Disease, Oslo University Hospital, Oslo, Norway.
Are Martin HolmInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Norwegian Institute of Public Health · NOOslo University Hospital · NOLovisenberg Diakonale Høgskole · NOSørlandet Sykehus · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aimed to assess whether gastrointestinal (GI) symptoms at admission are associated with increased short-term mortality in patients with invasive pneumococcal disease (IPD).

methodsWe included all patients with IPD at Aker University Hospital in Oslo, Norway, from 1993 to 2008. Clinical data were registered. Survival data were retrieved from official registries. We used Cox regression and Kaplan-Meier curve to compare mortality within 28 days of admission in patients with and without GI symptoms.

resultsFour hundred sixteen patients were included. Of these, 108 patients (26%) presented with GI symptoms, and 47 patients (11%) with GI symptoms only. Patients with GI symptoms were younger (p < 0.001) and had less cardiovascular disease (p < 0.001), pulmonary disease (p = 0.048), and cancer (p = 0.035) and received appropriate antibiotic treatment later. After adjusting for risk factors, we found an increased hazard ratio of 2.28 (95% CI 1.31-3.97) in patients presenting with GI symptoms. In patients with GI symptoms only there was an increased hazard ratio of 2.24 (95% CI 1.20-4.19) in univariate analysis, which increased to 4.20 (95% CI 2.11-8.39) after multivariate adjustment. Fewer patients with GI symptoms only received antibiotics upon admission.

conclusionsA large proportion of IPD patients present with GI symptoms only or in combination with other symptoms. GI symptoms in IPD are associated with increased short-term mortality.

Indexed as

AdultAgedAged, 80 and overAnti-Bacterial AgentsComorbidityFemaleGastrointestinal DiseasesHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedNorwayPneumococcal InfectionsProportional Hazards ModelsProspective StudiesAnti-Bacterial AgentsGastrointestinal symptomsInvasive pneumococcal diseaseMortalityPneumococcal bacteremiaSepsis

Identifiers

PMID32631331
PMCPMC7339559
OpenAlexW3039301646

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.