ArticleCardiovascular diabetology2020
Comparative predictive ability of visit-to-visit HbA1c variability measures for microvascular disease risk in type 2 diabetes.
Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Higher glucose fluctuation is associated with a higher risk of cardiovascular disease: Insights from pooled results among patients with diabetes.Journal of diabetes · 2023Pooled it
- HbA1c variability as an independent risk factor for diabetic retinopathy: results from a screening program.Acta diabetologica · 2026Article
- Multitask learning of longitudinal circulating biomarkers and clinical outcomes: identification of optimal machine-learning and deep-learning models.BMC medical informatics and decision making · 2026Article
- Interplay of glycated hemoglobin and traditional risk factors for the risk of atherosclerotic cardiovascular disease and all-cause mortality in people without diabetes.Cardiovascular diabetology · 2025Observational
- Determinants of HbA1c variability among type 2 diabetes mellitus patients in Malaysian primary care setting.Scientific reports · 2025Article
- The effect of HbA1C variability on the development and progression of diabetic nephropathy.Frontiers in clinical diabetes and healthcare · 2025Article
- Exploring the Link Between Diabetes, Herpes Zoster, and Post-Herpetic Neuralgia: Insights From Mendelian Randomization.Journal of pain research · 2025Article
- An interpretable predictive deep learning platform for pediatric metabolic diseases.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Prognostic value of longitudinal HbA1c variability in predicting the development of diabetic sensorimotor polyneuropathy among patients with type 2 diabetes mellitus: A prospective cohort observational study.Journal of diabetes investigation · 2024Observational
- Relationship Between Glycosylated Hemoglobin Variability and the Severity of Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus.Journal of diabetes research · 2024Article
- Effect of Preoperative Level of Glycemic Control with Pulsed Radiofrequency on the Incidence of Postherpetic Neuralgia in Patients with Herpes Zoster Combined with Type 2 Diabetes Mellitus: A Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Glycated hemoglobin variability and the risk of cardiovascular events in patients with prediabetes and type 2 diabetes mellitus: A post-hoc analysis of a prospective and multicenter study.Journal of diabetes investigation · 2023Observational
- Correlates of disordered eating and insulin restriction behavior and its association with psychological health in Taiwanese youths with diabetes mellitus.Journal of eating disorders · 2023Article
- Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis.Journal of Korean medical science · 2023Article
- Correlation Between Glycemic Variability and Diabetic Complications: A Narrative Review.International journal of general medicine · 2023Review
- A study of factors influencing long-term glycemic variability in patients with type 2 diabetes: a structural equation modeling approach.Frontiers in endocrinology · 2023Article
- HbA1c Variability and Cardiovascular Events in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy.European urology open science · 2023Article
- Associations Between Mean HbA1c, HbA1c Variability, and Both Mortality and Macrovascular Complications in Patients with Diabetes Mellitus: A Registry-Based Cohort Study.Clinical epidemiology · 2023Article
- Identification of robust deep neural network models of longitudinal clinical measurements.NPJ digital medicine · 2022Article
- Association of hemoglobin A1c time in range with risk for diabetes complications.BMJ open diabetes research & care · 2022Observational
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTo assess the associations of various HbA1c measures, including a single baseline HbA1c value, overall mean, yearly updated means, standard deviation (HbA1c-SD), coefficient of variation (HbA1c-CV), and HbA1c variability score (HVS), with microvascular disease (MVD) risk in patients with type 2 diabetes.
methodsLinked data between National Cheng Kung University Hospital and Taiwan's National Health Insurance Research Database were utilized to identify the study cohort. The primary outcome was the composite MVD events (retinopathy, nephropathy, or neuropathy) occurring during the study follow-up. Cox model analyses were performed to assess the associations between HbA1c measures and MVD risk, with adjustment for patients' baseline HbA1c, demographics, comorbidities/complications, and treatments.
resultsIn the models without adjustment for baseline HbA1c, all HbA1c variability and mean measures were significantly associated with MVD risk, except HVS. With adjustment for baseline HbA1c, HbA1c-CV had the strongest association with MVD risk. For every unit of increase in HbA1c-CV, the MVD risk significantly increased by 3.42- and 2.81-fold based on the models without and with adjustment for baseline HbA1c, respectively. The associations of HbA1c variability and mean measures with MVD risk in patients with baseline HbA1c < 7.5% (58 mmol/mol) were stronger compared with those in patients with baseline HbA1c ≥ 7.5% (58 mmol/mol).
conclusionsHbA1c variability, especially HbA1c-CV, can supplement conventional baseline HbA1c measure for explaining MVD risk. HbA1c variability may play a greater role in MVD outcomes among patients with relatively optimal baseline glycemic control compared to those with relatively poor baseline glycemic control.
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