ArticleRespiratory research2020
Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia.
Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- The Interrelationship between Liver Function Test and the Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.Iranian journal of medical sciences · 2021Pooled it
- Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial.Archives of medical research · 2022Trial
- The Clinical Risk Factors of Adenovirus Pneumonia in Children Based on the Logistic Regression Model: Correlation with Lactate Dehydrogenase.International journal of clinical practice · 2022Trial
- CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.Cell stress & chaperones · 2021Trial
- The diagnostic and therapeutic value of FDG PET/CT for infectious diseases in FUO/IUO patients.Annals of nuclear medicine · 2026Article
- Analysis of risk factors associated with in-hospital mortality in severe HIV-negative PCP patients: a retrospective cohort study.BMC infectious diseases · 2025Article
- Risk factors for severe COVID-19 and development of a predictive model.BMC pulmonary medicine · 2025Article
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- Clinical features and risk factors of adenovirus-related plastic bronchitis in children.Italian journal of pediatrics · 2025Article
- Serum Lactate Dehydrogenase Levels Reflect the Lung Injury Extension in COVID-19 Patients at Hospital Admission.Immunity, inflammation and disease · 2025Article
- Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism.International journal of general medicine · 2025Article
- Effects ofJournal of experimental pharmacology · 2025Article
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- Inflammatory, Hematological, and Biochemical Biomarkers in COVID-19 Patients.Immunity, inflammation and disease · 2024Article
- Integration of nanobiosensors into organ-on-chip systems for monitoring viral infections.Nano convergence · 2024Review
- The epidemiological characteristics of invasive pulmonary aspergillosis and risk factors for treatment failure: a retrospective study.BMC pulmonary medicine · 2024Article
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- Modulation in serum and hematological parameters as a prognostic indicator of COVID-19 infection in hypertension, diabetes mellitus, and different cardiovascular diseases.Frontiers in chemistry · 2024Article
- Evaluation of the association between inflammatory markers and the prognosis of Covid-19.Journal of family medicine and primary care · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in COVID-19 pneumonia has not been well investigated.
methodsStudy was performed in 87 cases confirmed by COVID-19 infection. The serum LDH levels were determined at diagnosis and follow-up visits. The evaluation of clinical response to therapy was based on chest CT scan. We selected the value of LDH around the data of chest CT scan (- 1 ~ + 1 day).
resultsAt diagnosis, significant differences in LDH levels were found between non-severe and severe group (P < 0.05). It was demonstrated that increase or decrease of LDH was indicative of radiographic progress or improvement (P < 0.05). The time to LDH normalization (5.67 ± 0.55, days) was positively correlated with the time to radiographic absorption (5.57 ± 0.65 days, r = 0.53, P < 0.05). Applying the cut-off value of the increase in LDH has good specificity to predict disease progression.
conclusionsSerum LDH was validated for its potential usefulness as markers for evaluating clinical severity and monitoring treatment response in COVID-19 pneumonia.
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