Evidence map›Paper›PMID 32631305›Full record

ArticleBMC pediatrics2020

Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study.

Giorgia Spinazzola, Roberta Costa, Daniele De Luca, Giovanna Chidini, Giuliano Ferrone, Marco Piastra, Giorgio Conti

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04360590 (Pressure Support Ventilation), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04360590 completednot on this map

Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilatory Assist (NAVA) in Difficult to Wean Pediatric ARDS Patients: a Physiologic Crossover Study

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2011 to 2014Enrolled12ConditionsDistress Respiratory Syndrome, Weaning FailureArmspressure support ventilation versus neurally adjusted ventilatory assist
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Giorgia SpinazzolaDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy. spinazzolagiorgia@yahoo.it.ORCID 0000-0001-8055-5142
Roberta CostaDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy.
Daniele De LucaDivision of Pediatric and Neonatal Critical Care, South Paris University Hospital, Medical Centers "A. Beclere" Assistance Publique-Hopitaux de Paris (APHP), Paris, France.
Giovanna ChidiniPediatric Intensive Care Unit, Department of Anesthesia, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Giuliano FerroneDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy.
Marco PiastraDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy.
Giorgio ContiDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy.
Agostino Gemelli University Polyclinic · ITAssistance Publique – Hôpitaux de Paris · FRFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurally adjusted ventilatory assist (NAVA) is an innovative mode for assisted ventilation that improves patient-ventilator interaction in children. The aim of this study was to assess the effects of patient-ventilator interaction comparing NAVA with pressure support ventilation (PSV) in patients difficult to wean from mechanical ventilation after moderate pediatric acute respiratory distress syndrome (PARDS).

methodsIn this physiological crossover study, 12 patients admitted in the Pediatric Intensive Care Unit (PICU) with moderate PARDS failing up to 3 spontaneous breathing trials in less than 7 days, were enrolled. Patients underwent three study conditions lasting 1 h each: PSV1, NAVA and PSV2.

resultsThe Asynchrony Index (AI) was significantly reduced during the NAVA trial compared to both the PSV1 and PSV2 trials (p = 0.001). During the NAVA trial, the inspiratory and expiratory trigger delays were significantly shorter compared to those obtained during PSV1 and PSV2 trials (Delay

conclusionsIn this specific PICU population, presenting difficulty in weaning after PARDS, NAVA was associated with a reduction of the AI and a significant improvement in oxygenation compared to PSV mode.

trial registrationClinicalTrial.gov Identifier: NCT04360590 "Retrospectively registered".

Indexed as

Interactive Ventilatory SupportRespiratory Distress SyndromeChildCross-Over StudiesHumansPositive-Pressure RespirationRespiration, ArtificialRetrospective StudiesMechanical ventilationNeurally adjusted ventilatory assistPatient-ventilator interactionPediatric acute respiratory distress syndromeWeaning

Identifiers

PMID32631305
PMCPMC7338290
OpenAlexW3038977145

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.