Evidence map›Paper›PMID 32631262›Full record

ArticleBMC neurology2020

Changing the paradigm of intracranial hypertension in brain tumor patients: a study based on non-invasive ICP measurements.

Jenny C Kienzler, Rolandas Zakelis, Serge Marbacher, Sabrina Bäbler, Lucia Schwyzer, Elke Remonda, Javier Fandino

Open access · goldAbstract read
In one paragraph

Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jenny C KienzlerDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland. jenny.kienzler@ksa.ch.ORCID http://orcid.org/0000-0003-2480-0451
Rolandas ZakelisDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland.
Serge MarbacherDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland.
Sabrina BäblerDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland.
Lucia SchwyzerDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland.
Elke RemondaDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland.
Javier FandinoDepartment of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland.
Kantonsspital Aarau · CHKaunas University of Technology · LT

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 32003B_173341
6 · The paper itself

Abstract

backgroundThe ultrasound based non-invasive ICP measurement method has been recently validated. Correlation of symptoms and signs of intracranial hypertension with actual ICP measurements in patients with large intracranial tumors is controversial. The purpose of this study was to assess ICP in patients with brain tumors, presenting with neurological signs and symptoms of elevated ICP and to further evaluate the value and utility of non-invasive ICP monitoring.

methodsTwenty patients underwent non-invasive ICP measurement using a two-depth transcranial Doppler ultrasound designed to simultaneously compare pulse dynamics in the proximal (intracranial), and the distal (extracranial) intraorbital segments of the ophthalmic artery through the closed eyelid.

resultsForty-eight measurements were analyzed. Radiological characteristics included tumor volume (range = 5.45-220.27cm

conclusionsThis study demonstrated that ICP in patients with intracranial tumors and mass effect is not necessarily increased. Therefore, clinical signs of intracranial hypertension do not necessarily reflect increased ICP.

Indexed as

AdultAgedAged, 80 and overBrain NeoplasmsFemaleHumansIntracranial HypertensionIntracranial PressureMaleMiddle AgedMonitoring, PhysiologicOphthalmic ArteryPilot ProjectsUltrasonography, Doppler, TranscranialBrain tumorIntracranial hypertensionIntracranial pressureNon-invasive ICP measurement

Identifiers

PMID32631262
PMCPMC7336443
OpenAlexW3038482369

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.