Evidence map›Paper›PMID 32631251›Full record

ArticleThe journal of headache and pain2020

Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization.

Andrea Negro, Jessica L Seidel, Thijs Houben, Esther S Yu, Ike Rosen, Andrea J Arreguin, Nilufer Yalcin, Lea Shorser-Gentile, Lea Pearlman, Homa Sadhegian and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05742191 (The Effect of Daylight Saving Time Transitions on Sleep and Migraine Headaches.), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05742191 unknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Daylight Saving Time Transitions on Sleep and Migraine Headaches.

TypeobservationalSponsorOSF Healthcare SystemRan2023 to 2023Enrolled50ConditionsEpisodic MigraineArmsDaylight Savings time transitions
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Estrogen modulation of cortical spreading depression.The journal of headache and pain · 2023
    Article
  12. Article
  13. The association between multidimensional sleep health and migraine burden among patients with episodic migraine.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  14. Review
  15. Headache in people with epilepsy.Nature reviews. Neurology · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Andrea NegroNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jessica L SeidelNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Thijs HoubenNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Esther S YuNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ike RosenNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Andrea J ArreguinNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Nilufer YalcinNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Lea Shorser-GentileNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Lea PearlmanNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Homa SadhegianNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ramalingam VetrivelanDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nancy L ChamberlinDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.
Cenk AyataNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Michael A MoskowitzDepartment of Radiology, and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Katharina Eikermann-HaerterNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. khaerter@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5059-6012
Harvard University · USBeth Israel Deaconess Medical Center · USBoston Children's Hospital · USSapienza University of Rome · IT

Funding

Neural mechanisms underlying REM sleep regulation by MCH neuronsR01NS088482 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RAMALINGAM, VETRIVELAN · 2015 to 2019
$1.9M
American Heart Association 10SDG2610275NINDS NIH HHS R01 NS088482
6 · The paper itself

Abstract

backgroundMigraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarization. Sleep disorders are well known risk factors for migraine chronification, and changes in wake-sleep pattern such as sleep deprivation are common migraine triggers. The underlying mechanisms are unknown. As a step towards developing an animal model to study this, we test whether sleep deprivation, a modifiable migraine trigger, enhances CSD susceptibility in rodent models.

methodsAcute sleep deprivation was achieved using the "gentle handling method", chosen to minimize stress and avoid confounding bias. Sleep deprivation was started with onset of light (diurnal lighting conditions), and assessment of CSD was performed at the end of a 6 h or 12 h sleep deprivation period. The effect of chronic sleep deprivation on CSD was assessed 6 weeks or 12 weeks after lesioning of the hypothalamic ventrolateral preoptic nucleus. All experiments were done in a blinded fashion with respect to sleep status. During 60 min of continuous topical KCl application, we assessed the total number of CSDs, the direct current shift amplitude and duration of the first CSD, the average and cumulative duration of all CSDs, propagation speed, and electrical CSD threshold.

resultsAcute sleep deprivation of 6 h (n = 17) or 12 h (n = 11) duration significantly increased CSD frequency compared to controls (17 ± 4 and 18 ± 2, respectively, vs. 14 ± 2 CSDs/hour in controls; p = 0.003 for both), whereas other electrophysiological properties of CSD were unchanged. Acute total sleep deprivation over 12 h but not over 6 h reduced the electrical threshold of CSD compared to controls (p = 0.037 and p = 0.095, respectively). Chronic partial sleep deprivation in contrast did not affect CSD susceptibility in rats.

conclusionsAcute but not chronic sleep deprivation enhances CSD susceptibility in rodents, possibly underlying its negative impact as a migraine trigger and exacerbating factor. Our findings underscore the importance of CSD as a therapeutic target in migraine and suggest that headache management should identify and treat associated sleep disorders.

Indexed as

AnimalsCortical Spreading DepressionDisease Models, AnimalMaleMigraine without AuraRatsRats, Sprague-DawleySleep DeprivationCortical spreading depolarizationCSDMigraineSleep deprivationVentrolateral preoptic (VLPO) nucleusVLPO

Identifiers

PMID32631251
PMCPMC7339460
OpenAlexW3039459813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.