ArticleClinical and experimental otorhinolaryngology2021
Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines.
Article in Clinical and experimental otorhinolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Do Skin Prick Tests Predict Nasal Provocation Test Outcomes in Allergic Rhinitis Patients?International forum of allergy & rhinology · 2025Article
- Variability of Diagnostic Outcomes in Nasal Allergen Challenge: The Role of Combined Subjective and Objective Indicators.Clinical and translational allergy · 2025Article
- Chronic Rhinosinusitis With Nasal Polyps Does Not Affect the Association Between the Nasal Provocation Test and Serum Allergen-Specific Immunoglobulin E Levels.Journal of rhinology : official journal of the Korean Rhinologic Society · 2024Article
- Selection of allergen extract for immunotherapy in polysensitized allergic rhinitis patients.Immunotherapy · 2024Article
- [Research progress and clinical application of allergen nasal provocation test].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Appropriate Antigen Concentrations and Timing of a Nasal Provocation Test.Yonsei medical journal · 2021Article
- Precision Medicine in Mite Allergic Rhinitis.Frontiers in allergy · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe evaluated the usefulness of the standardized nasal provocation test (NPT) protocol recently published by the European Academy of Allergy and Clinical Immunology (EAACI) and compared the utility of several parameters for diagnosing allergic rhinitis (AR) caused by house dust mites (HDM). Subjective parameters were nasal and ocular symptoms measured using a visual analog scale (VAS), and objective parameters were peak nasal inspiratory flow (PNIF), minimal cross-sectional area (MCA), and total nasal volume (TNV).
methodsBefore and after spraying Dermatophagoides pteronyssinus (DP) allergen (1,000 AU/mL, 100 μL) into both nostrils of 13 patients with AR (AR group) and 22 patients with non-AR (NAR group), we used VAS scores to measure nasal symptoms (nasal obstruction, rhinorrhea, sneezing, and itching) and ocular symptoms and assessed PNIF, MCA, and TNV.
resultsThe AR group had significantly worse symptoms than the NAR group 15 minutes after DP challenge (P<0.001). After 30 minutes, nasal obstruction and rhinorrhea remained worse in the AR group (P<0.001); a similar but less marked difference was seen for sneezing (P=0.012) and itching (P=0.039). Ocular symptoms, PNIF, MCA, and TNV differed between groups after both 15 and 30 minutes (P<0.05). The area under the receiver operating characteristic curve was higher for nasal obstruction (0.977), rhinorrhea (0.906), and TNV (0.979) than for sneezing (0.755), itching (0.673), and MCA (0.836).
conclusionNPT performed according to the EAACI guidelines could help diagnose AR caused by HDM. TNV and VAS changes in nasal obstruction and rhinorrhea had higher diagnostic accuracy than other parameters.
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