Evidence map›Paper›PMID 32630948›Full record

ArticleOptics letters2020

Time-gated luminescence imaging for background free in vivo tracking of single circulating tumor cells.

Xu Cao, Cuiping Yao, Shudong Jiang, Jason Gunn, Austin C Van Namen, Petr Bruza, Brian W Pogue

Abstract read
In one paragraph

Article in Optics letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Development of Time-Resolved Luminescence Measurement Instruments for Biosensing and Bioimaging - An Overview.Measurement : journal of the International Measurement Confederation · 2025
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xu Cao
Cuiping Yao
Shudong Jiang
Jason Gunn
Austin C Van Namen
Petr Bruza
Brian W Pogue

Funding

Cerenkov excited luminescence sheet imaging (CELSI)R01EB024498 · NIBIB · DARTMOUTH COLLEGE · PI POGUE, BRIAN WILLIAM · 2017 to 2020
$2.2M
NIBIB NIH HHS R01 EB024498
6 · The paper itself

Abstract

Fluorescence imaging is severely limited by the background and autofluorescence of tissues for in vivo detection of circulating tumor cells (CTCs). Time-gated luminescence (TGL) imaging, in combination with luminescent probes that possess hundreds of microsecond emission lifetimes, can be used to effectively suppress this background, which has predominantly nanosecond lifetimes. This Letter demonstrates the feasibility of TGL imaging using luminescent probes for the in vivo real time imaging and tracking of single CTCs circulating freely in the blood vessels with higher accuracy given by substantially higher signal-to-noise ratio. The luminescent probe used in this Letter was a commercial

Indexed as

LuminescenceAnimalsCell Line, TumorHumansMiceNeoplastic Cells, CirculatingOptical ImagingSignal-To-Noise RatioSingle-Cell AnalysisTime Factors

Identifiers

PMID32630948
PMCPMC12980755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.