Evidence map›Paper›PMID 32630756›Full record

ReviewAnimals : an open access journal from MDPI2020

MicroRNA Milk Exosomes: From Cellular Regulator to Genomic Marker.

Michela Cintio, Giulia Polacchini, Elisa Scarsella, Tommaso Montanari, Bruno Stefanon, Monica Colitti

Open access · goldAbstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Psychological Stress Increases the Expression of Milk-Derived miR-210-5p.Journal of mammary gland biology and neoplasia · 2026
    Article
  5. Article
  6. Camel (Biology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Regulatory Role of microRNA of Milk Exosomes in Mastitis of Dairy Cows.Animals : an open access journal from MDPI · 2023
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michela CintioDepartment of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.
Giulia PolacchiniDepartment of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.
Elisa ScarsellaDepartment of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.
Tommaso MontanariDepartment of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.
Bruno StefanonDepartment of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.
Monica ColittiDepartment of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.
University of Udine · IT

Funding

Ministero delle Politiche Agricole Alimentari e Forestali G48D19000410001
6 · The paper itself

Abstract

Recent advances in ruminants' milk-derived exosomes (EXO) have indicated a role of microRNAs (miRNAs) in cell-to-cell communication in dairy ruminants. The miRNAs EXO retain peculiar mechanisms of uptake from recipient cells, which enables the selective delivery of cargos, with a specific regulation of target genes. Although many studies have been published on the miRNAs contained in milk, less information is available on the role of miRNAs EXO, which are considered stable over time and resistant to digestion and milk processing. Several miRNAs EXO have been implicated in the cellular signaling pathway, as in the regulation of immune response. Moreover, they exert epigenetic control, as extenuating the expression of DNA methyltransferase 1. However, the study of miRNAs EXO is still challenging due to the difficulty of isolating EXO. In fact, there are not agreed protocols, and different methods, often time-consuming, are used, making it difficult to routinely process a large number of samples. The regulation of cell functions in mammary glands by miRNAs EXO, and their applications as genomic markers in livestock, is presented.

Indexed as

bovine milkexosomesgenomemastitismiRNAruminants

Identifiers

PMID32630756
PMCPMC7401532
OpenAlexW3039251416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.