Evidence map›Paper›PMID 32630668›Full record

ArticleInternational journal of molecular sciences2020

Stearoyl-CoA Desaturase-1 Attenuates the High Shear Force Damage Effect on Human MG63 Osteosarcoma Cells.

Kuo-Chin Huang, Po-Yao Chuang, Rong-Ze Hsieh, Cheng-Nan Chen, Shun-Fu Chang, Yu-Ping Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kuo-Chin HuangDepartment of Orthopaedics, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Po-Yao ChuangDepartment of Orthopaedics, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Rong-Ze HsiehGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Cheng-Nan ChenDepartment of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan.
Shun-Fu ChangDepartment of Medical Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.ORCID 0000-0002-2276-7785
Yu-Ping SuDepartment of Orthopaedics and Traumatology, Veterans General Hospital, Taipei 112, Taiwan.
Chang Gung University · TWNational Chiayi University · TWChiayi Chang Gung Memorial Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

Chiayi Chang Gung Memorial Hospital CMRPG6H0231-0232Chiayi Chang Gung Memorial Hospital CMRPG6H0421Ministry of Science and Technology, Taiwan MOST 106-2314-B-182A-010-MY3Ministry of Science and Technology, Taiwan MOST 107-2314-B-182A-125Taipei Veterans General Hospital V105C-23Taipei Veterans General Hospital V106C-127Taipei Veterans General Hospital V108C-191
6 · The paper itself

Abstract

Mechanical regulation is known as an important regulator in cancer progression and malignancy. High shear force has been found to inhibit the cell cycle progression and result in cell death in various cancer cells. Stearoyl-CoA desaturase (SCD)-1, one of the important lipogenic enzymes, has recently been indicated as a potential pharmaceutical target in cancer therapy. In this study, we determined whether the cell fate control of shear force stimulation is through regulating the SCD-1 expression in cancer cells. Human MG63 osteosarcoma cells were used in this study. 2 and 20 dynes/cm

Indexed as

Cell Line, TumorHumansLipogenesisOsteosarcomaPPAR deltaShear StrengthSignal TransductionSmad ProteinsStearoyl-CoA DesaturaseStress, MechanicalTranscriptional ActivationPPAR deltaSmad ProteinsStearoyl-CoA Desaturasehigh shear forceosteosarcomaperoxisome proliferator-activated receptor δSmad1/5Stearoyl-CoA desaturase-1

Identifiers

PMID32630668
PMCPMC7369751
OpenAlexW3039829250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.