Evidence map›Paper›PMID 32630523›Full record

ArticleMarine drugs2020

Protective Effect of Fucoidan against MPP

Huaide Liu, Jing Wang, Quanbin Zhang, Lihua Geng, Yue Yang, Ning Wu

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Pulmonary fibrosis: from mechanisms to therapies.Journal of translational medicine · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. eEF1A2 siRNA Suppresses MPPTheScientificWorldJournal · 2023
    Article
  14. Neuroprotective Effects of Oligosaccharides FromFrontiers in pharmacology · 2022
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Huaide LiuSchool of Life Sciences, Nantong University, Seyuan Road 9, Nantong 226019, China.
Jing WangKey Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Quanbin ZhangKey Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Lihua GengKey Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Yue YangKey Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.ORCID 0000-0002-7736-0405
Ning WuKey Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Chinese Academy of Sciences · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main pathologic changes of the Parkinson's disease (PD) is dopaminergic (DA) neurons lost. Apoptosis was one of the important reasons involved in the DA lost. Our previous study found a fucoidan fraction sulfated heterosaccharide (UF) had neuroprotective activity. The aim of this study was to clarify the mechanism of UF on DA neurons using human dopaminergic neuroblastoma (SH-SY5Y) cells a typical as a PD cellular model. Results showed that UF prevented MPP

Indexed as

1-Methyl-4-phenylpyridiniumApoptosisbcl-2-Associated X ProteinCaspasesCell Line, TumorChromonesHumansMorpholinesNeuroblastomaNeuroprotective AgentsParkinson DiseasePhosphatidylinositol 3-KinasesPolysaccharidesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Signal Transduction1-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCaspasesChromonesfucoidanMorpholinesNeuroprotective AgentsPhosphatidylinositol 3-KinasesPolysaccharidesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2dopamine neurons apoptosisfucoidanPI3K–Aktsulfated heterosaccharide

Identifiers

PMID32630523
PMCPMC7344518
OpenAlexW3038045976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.