Evidence map›Paper›PMID 32630522›Full record

ArticleMolecules (Basel, Switzerland)2020

Antifungal Agent 4-AN Changes the Genome-Wide Expression Profile, Downregulates Virulence-Associated Genes and Induces Necrosis in

Aleksandra Martyna, Maciej Masłyk, Monika Janeczko, Elżbieta Kochanowicz, Bartłomiej Gielniewski, Aleksandra Świercz, Oleg M Demchuk, Konrad Kubiński

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Frontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aleksandra MartynaDepartment of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Maciej MasłykDepartment of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.ORCID 0000-0003-0516-3231
Monika JaneczkoDepartment of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.ORCID 0000-0002-4057-6931
Elżbieta KochanowiczDepartment of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.ORCID 0000-0002-8065-1203
Bartłomiej GielniewskiLaboratory of Molecular Neurobiology, Neurobiology Center, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.
Aleksandra ŚwierczInstitute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznań, Poland.ORCID 0000-0002-5574-8222
Oleg M DemchukPharmaceutical Research Institute, Rydygiera Street 8, 01-793 Warsaw, Poland.ORCID 0000-0002-5571-1593
Konrad KubińskiDepartment of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.ORCID 0000-0001-6870-845X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the light of the increasing occurrence of antifungal resistance, there is an urgent need to search for new therapeutic strategies to overcome this phenomenon. One of the applied approaches is the synthesis of small-molecule compounds showing antifungal properties. Here we present a continuation of the research on the recently discovered anti-

Indexed as

Genome, FungalNecrosisAntifungal AgentsBiofilmsCandida albicansFungal ProteinsGene Expression ProfilingGene Expression Regulation, FungalVirulenceAntifungal AgentsFungal Proteins4-ANantifungalsC. albicansgene expressionnecrosissynergy

Identifiers

PMID32630522
PMCPMC7356344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.