Evidence map›Paper›PMID 32630476›Full record

ArticleMolecules (Basel, Switzerland)2020

Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats.

Farah Deba, Kara Ramos, Matthew Vannoy, Kemburli Munoz, Lois S Akinola, M Imad Damaj, Ayman K Hamouda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Farah DebaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Texas at Tyler, Tyler, TX 75799, USA.
Kara RamosDepartment of Pharmaceutical Sciences, College of Pharmacy, Texas A&M Health Sciences Center MS 131, 1010 W. Ave. B, Kingsville, TX 78363, USA.
Matthew VannoyDepartment of Pharmaceutical Sciences, College of Pharmacy, Texas A&M Health Sciences Center MS 131, 1010 W. Ave. B, Kingsville, TX 78363, USA.
Kemburli MunozDepartment of Pharmaceutical Sciences, College of Pharmacy, Texas A&M Health Sciences Center MS 131, 1010 W. Ave. B, Kingsville, TX 78363, USA.
Lois S AkinolaDepartment of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Kontos Medical Science Building, 1217 E. Marshall St., P.O. Box 980613, Richmond, VA 23298, USA.ORCID 0000-0003-0168-4515
M Imad DamajDepartment of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Kontos Medical Science Building, 1217 E. Marshall St., P.O. Box 980613, Richmond, VA 23298, USA.
Ayman K HamoudaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Texas at Tyler, Tyler, TX 75799, USA.
The University of Texas at Tyler · USVirginia Commonwealth University Medical Center · US

Funding

Virginia Commonwealth University Initiative for Maximizing Student DevelopmentR25GM090084 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, LLOYD, JOYCE A. · 2010 to 2022
$5.2M
NIGMS NIH HHS R25 GM090084
6 · The paper itself

Abstract

Neuronal nicotinic acetylcholine receptor (nAChR)-based therapeutics are sought as a potential alternative strategy to opioids for pain management. In this study, we examine the antinociceptive effects of 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1

Indexed as

Hot TemperatureAllosteric RegulationAnimalsHydrocarbons, BrominatedIsoxazolesMaleNicotinic AgonistsNociceptionPain ThresholdPyrazolesRatsRats, Sprague-DawleyReceptors, NicotinicHydrocarbons, BrominatedIsoxazolesNicotinic Agonistsnicotinic receptor alpha4beta2pyrazolePyrazolesReceptors, Nicotinicacute thermal nociceptionCMPIdesformylflustrabromine (dFBr)hot platenicotinic acetylcholine receptors (nAChRs)positive allosteric modulators (PAMs)tail flick

Identifiers

PMID32630476
PMCPMC7355939
OpenAlexW3037425122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.