Evidence map›Paper›PMID 32630457›Full record

ArticlePharmaceutics2020

In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy.

Mingjuan Li, M Ingmar van Raath, Shervin Khakpour, Ahmet Seçilir, Bart C Sliggers, Xuan Huang, Baoyue Ding, Gert Storm, René R van der Hulst, Anton I P M de Kroon and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Stimuli-responsive vesicles as distributed artificial organelles for bacterial activation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingjuan LiDepartment of Pharmaceutics, Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, College of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China.
M Ingmar van RaathDepartment of Pharmaceutics, Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, College of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China.
Shervin KhakpourMembrane Biochemistry and Biophysics, Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands.
Ahmet SeçilirMembrane Biochemistry and Biophysics, Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands.
Bart C SliggersDepartment of Medical Innovation and Development, Amsterdam University Medical Centers, location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Xuan HuangDepartment of Pharmaceutics, Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, College of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China.
Baoyue DingDepartment of Pharmaceutics, Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, College of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China.
Gert StormDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
René R van der HulstDepartment of Plastic, Reconstructive, and Hand Surgery, Maastricht University Medical Center, Maastricht University, 3229 HX Maastricht, The Netherlands.
Anton I P M de KroonMembrane Biochemistry and Biophysics, Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands.
Michal HegerDepartment of Pharmaceutics, Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, College of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China.ORCID 0000-0002-0630-4465

Funding

Academic Medical Center SKE Fund Technostarter # 20090812Grant for the establishment of the Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics *KWF Kankerbestrijding project # 10666National Natural Science Foundation of China 81872220Stichting Technologische Wetenschappen 12064Zhejiang Provincial Foreign Expert Program Grant *Zhejiang Provincial Key Natural Science Foundation of China #Z20H160031
6 · The paper itself

Abstract

Antifibrinolytic site-specific pharmaco-laser therapy (SSPLT) is an experimental treatment modality for refractory port wine stains (PWS). Conceptually, antifibrinolytic drugs encapsulated in thermosensitive liposomes are delivered to thrombi that form in semi-photocoagulated PWS blood vessels after conventional laser treatment. Local release of antifibrinolytics is induced by mild hyperthermia, resulting in hyperthrombosis and complete occlusion of the target blood vessel (clinical endpoint). In this study, 20 thermosensitive liposomal formulations containing tranexamic acid (TA) were assayed for physicochemical properties, TA:lipid ratio, encapsulation efficiency, and endovesicular TA concentration. Two candidate formulations (DPPC:DSPE-PEG, DPPC:MPPC:DSPE-PEG) were selected based on optimal properties and analyzed for heat-induced TA release at body temperature (T), phase transition temperature (T

Indexed as

endovascular laser-tissue interactionsfluorescent thrombus staininghyperthermiaintravital fluorescence microscopytargeted drug deliverythrombosistranexamic acidvascular malformations

Identifiers

PMID32630457
PMCPMC7356038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.