Evidence map›Paper›PMID 32630321›Full record

ArticleInternational journal of environmental research and public health2020

Subclinical Atherosclerosis Markers of Carotid Intima-Media Thickness, Carotid Plaques, Carotid Stenosis, and Mortality in Community-Dwelling Adults.

Chuan-Wei Yang, Yuh-Cherng Guo, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Chung-Hsiang Liu, Mu-Cyun Wang, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin

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In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chuan-Wei YangDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.
Yuh-Cherng GuoDepartment of Neurology, China Medical University Hospital, 404, Taiwan.
Chia-Ing LiDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.
Chiu-Shong LiuSchool of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
Chih-Hsueh LinSchool of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
Chung-Hsiang LiuDepartment of Neurology, China Medical University Hospital, 404, Taiwan.
Mu-Cyun WangSchool of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
Shing-Yu YangDepartment of Public Health, College of Public Health, China Medical University, Taichung 404, Taiwan.
Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, Taichung 404, Taiwan.
Cheng-Chieh LinSchool of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid intima-media thickness (IMT), plaque, and stenosis are widely used as early surrogate markers of subclinical atherosclerosis and strong predictors of future deaths and cardiovascular events. Albuminuria is an indicator of generalized endothelial dysfunction that speeds up atherosclerosis. However, previous studies reporting these associations cannot rule out the confounding effect of albuminuria. We aimed to examine the independent and joint relationships between IMT markers and 10-year mortality in community-dwelling Taiwanese adults. This work was a community-based prospective cohort study consisting of 2956 adults aged at least 30 years recruited in 2007 and followed up through 2019. Cox proportional hazard regression models were used to examine associations of these subclinical atherosclerosis markers with mortality. During an average of 9.41 years of follow up, 242 deaths occurred. The mortality rate was 8.70 per 1000 person-years. Compared with those with carotid IMT less than 1.0 mm, persons with severely increased carotid IMT (≥2.0 mm) had an increased risk for death (hazard ratio (HR): 1.79; 95% confidence interval (CI): 1.07, 3.00). Compared with those without carotid plaque, persons with carotid plaque were more likely to have an increased risk for death (1.65; 1.21-2.32). Compared with those with carotid stenosis less than 25%, persons with carotid stenosis of 25-36% had a significant increased risk for death (1.57; 1.12-2.22). Considering these three IMT markers along with the traditional risk factors (c-statistic: 0.85) significantly increased their predictive ability of mortality compared with any individual variable's predictive ability (all

Indexed as

Carotid Intima-Media ThicknessAdultAtherosclerosisBiomarkersCarotid ArteriesCarotid StenosisHumansIndependent LivingProspective StudiesRisk FactorsTaiwanBiomarkersintima–media thicknessmortalityplaquestenosis

Identifiers

PMID32630321
PMCPMC7369727
OpenAlexW3040431073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.