Evidence map›Paper›PMID 32630206›Full record

ArticleViruses2020

Long Term Delta-9-tetrahydrocannabinol Administration Inhibits Proinflammatory Responses in Minor Salivary Glands of Chronically Simian Immunodeficieny Virus Infected Rhesus Macaques.

Xavier Alvarez, Karol Sestak, Siddappa N Byrareddy, Mahesh Mohan

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. The impact of cannabinoids on inflammasome signaling in HIV-1 infection.NeuroImmune pharmacology and therapeutics · 2023
    Review
  7. Article
  8. Review
  9. Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Xavier AlvarezSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Karol SestakPreCliniTria, LLC., Mandeville, LA 70471, USA.
Siddappa N ByrareddyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-6889-4640
Mahesh MohanSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0003-4360-3277
Texas Biomedical Research Institute · USTulane University · USUniversity of Nebraska Medical Center · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Role of microRNAs in B-cell dysfunction in HIV/SIV infectionR01DA042524 · NIDA · TULANE UNIVERSITY OF LOUISIANA · PI MOHAN, MAHESH · 2016 to 2020
$4.2M
Cannabinoid modulation of EV composition and function in HIV/SIV infectionR01DA050169 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOHAN, MAHESH, OKEOMA, CHIOMA M · 2019 to 2023
$3.8M
The effect of HIV and cocaine abuse on semen exosome composition and functionR01DA042348 · NIDA · UNIVERSITY OF IOWA · PI OKEOMA, CHIOMA M · 2016 to 2020
$2.7M
NIDA NIH HHS R01 DA042348NIDA NIH HHS R01 DA042524NIDA NIH HHS R01 DA050169NIH HHS P51 OD011104NIH HHS P51 OD011133
6 · The paper itself

Abstract

HIV/SIV-associated oral mucosal disease/dysfunction (HAOMD) (gingivitis/periodontitis/salivary adenitis) represents a major comorbidity affecting HIV patients on anti-retroviral therapy. Using a systems biology approach, we investigated molecular changes (mRNA/microRNA) underlying HAOMD and its modulation by phytocannabinoids (delta-9-tetrahydrocannabinol (∆

Indexed as

AnimalsAnti-Inflammatory AgentsDronabinolHIVHIV InfectionsHumansInterferonsMacaca mulattaMaleMicroRNAsSalivary Gland DiseasesSalivary Glands, MinorSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadAnti-Inflammatory AgentsDronabinolInterferonsMicroRNAsHIV/SIVminor salivary gland inflammationmiR-29brhesus macaqueTHC

Identifiers

PMID32630206
PMCPMC7412369
OpenAlexW3039262266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.