Evidence map›Paper›PMID 32630159›Full record

ArticleInternational journal of molecular sciences2020

Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity.

Natalia Ptaszyńska, Katarzyna Gucwa, Katarzyna Olkiewicz, Mateusz Heldt, Marcin Serocki, Anna Stupak, Dorota Martynow, Dawid Dębowski, Agata Gitlin-Domagalska, Jan Lica and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Efficacy of enoxacin and levofloxacin againstIranian journal of veterinary research · 2025
    Article
  3. Review
  4. Silver ciprofloxacin (CIPAG): a multitargeted metallodrug in the development of breast cancer therapy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential.International journal of molecular sciences · 2023
    Article
  9. Various Biomimetics, Including Peptides as Antifungals.Biomimetics (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Natalia PtaszyńskaDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Katarzyna GucwaDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Katarzyna OlkiewiczDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Mateusz HeldtDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, 80-233 Gdańsk, Poland.
Marcin SerockiDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, 80-233 Gdańsk, Poland.
Anna StupakLaboratory of Bacterial Genetics, Faculty of Chemistry, Gdansk University of Technology, 80-233 Gdańsk, Poland.
Dorota MartynowDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, 80-233 Gdańsk, Poland.
Dawid DębowskiDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Agata Gitlin-DomagalskaDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Jan LicaDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Anna ŁęgowskaDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
Sławomir MilewskiDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, 80-233 Gdańsk, Poland.
Krzysztof RolkaDepartment of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, 80-008 Gdańsk, Poland.
University of Gdańsk · PLGdańsk University of Technology · PL

Funding

Narodowe Centrum Nauki UMO-2016/21/B/ST5/0010
6 · The paper itself

Abstract

Seven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH

Indexed as

Cell-Penetrating PeptidesCiprofloxacinLevofloxacinRecombinant Fusion ProteinsAnimalsAnti-Infective AgentsAntineoplastic AgentsCandidaDrug Resistance, BacterialHEK293 CellsHep G2 CellsHL-60 CellsHumansMicrobial Sensitivity TestsSwineAnti-Infective AgentsAntineoplastic AgentsCell-Penetrating PeptidesCiprofloxacinLevofloxacinRecombinant Fusion Proteinstransportan-10antimicrobial agentsbacteriostatic and mycostatic agentscell-penetrating peptide (CPP)ciprofloxacin bioconjugateslevofloxacin bioconjugatesredox-resistant and redox-sensitive linkerstransportan 10 (TP10-NH2)

Identifiers

PMID32630159
PMCPMC7369900
OpenAlexW3039605276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.