Evidence map›Paper›PMID 32630112›Full record

ArticleBiomolecules2020

Unveiling the Mechanism of Action of 7α-acetoxy-6β-hydroxyroyleanone on an MRSA/VISA Strain: Membrane and Cell Wall Interactions.

Filipe Pereira, Teresa Figueiredo, Rodrigo F M de Almeida, Catarina A C Antunes, Catarina Garcia, Catarina P Reis, Lia Ascensão, Rita G Sobral, Patricia Rijo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Comparative proteomic analysis of vancomycin-sensitive and vancomycin-intermediate resistant Staphylococcus aureus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  4. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Filipe PereiraResearch Center for Biosciences and Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande, 376, 1749-024 Lisboa, Portugal.
Teresa FigueiredoDepartamento de Ciências da Vida, UCIBIO@REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2825-149 Caparica, Portugal.
Rodrigo F M de AlmeidaCentro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.ORCID 0000-0002-9748-7083
Catarina A C AntunesCentro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Catarina GarciaResearch Center for Biosciences and Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande, 376, 1749-024 Lisboa, Portugal.
Catarina P ReisInstituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.ORCID 0000-0002-1046-4031
Lia AscensãoCentro de Estudos do Ambiente e do Mar (CESAM), Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.ORCID 0000-0001-7439-5912
Rita G SobralDepartamento de Ciências da Vida, UCIBIO@REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2825-149 Caparica, Portugal.
Patricia RijoResearch Center for Biosciences and Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande, 376, 1749-024 Lisboa, Portugal.ORCID 0000-0001-7992-8343
University of Lisbon · PTRede de Química e Tecnologia · PTUniversidad de Alcalá · ES

Funding

Fundação para a Ciência e a Tecnologia UIDB/04378/2020Fundação para a Ciência e a Tecnologia UID/DTP/04567/2019Fundação para a Ciência e a Tecnologia UID/Multi/00612/2013 (CQB)
6 · The paper itself

Abstract

The number of cases of failure in the treatment of infections associated with resistant bacteria is on the rise, due to the decreasing efficacy of current antibiotics. Notably, 7α-Acetoxy-6β-hydroxyroyleanone (AHR), a diterpene isolated from different

Indexed as

Bacterial Outer MembraneCell MembraneCell Membrane PermeabilityCell WallDiterpenesHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicrobial ViabilityVancomycin-Resistant Staphylococcus aureus7-acyloxy-6-hydroxyroyleanoneDiterpenes7α-Acetoxy-6β-hydroxyroyleanoneantibacterial activitycell wallmembrane interactionMRSA

Identifiers

PMID32630112
PMCPMC7408375
OpenAlexW3040403675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.