Evidence map›Paper›PMID 32630015›Full record

ArticleInternational journal of molecular sciences2020

Protein Kinase CK2 Controls Ca

Rebecca Scheuer, Stephan Ernst Philipp, Alexander Becker, Lisa Nalbach, Emmanuel Ampofo, Mathias Montenarh, Claudia Götz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rebecca ScheuerDepartment of Medical Biochemistry and Molecular Biology, Saarland University, Kirrberger Str., bldg. 44, D-66424 Homburg, Germany.
Stephan Ernst PhilippDepartment of Experimental and Clinical Pharmacology and Toxicology, Saarland University Kirrberger Str., bldg. 45-46, D-66424 Homburg, Germany.
Alexander BeckerDepartment of Experimental and Clinical Pharmacology and Toxicology, Saarland University Kirrberger Str., bldg. 45-46, D-66424 Homburg, Germany.
Lisa NalbachInstitute for Clinical & Experimental Surgery, Saarland University Kirrberger Str., bldg. 65, D-66424 Homburg, Germany.
Emmanuel AmpofoInstitute for Clinical & Experimental Surgery, Saarland University Kirrberger Str., bldg. 65, D-66424 Homburg, Germany.
Mathias MontenarhDepartment of Medical Biochemistry and Molecular Biology, Saarland University, Kirrberger Str., bldg. 44, D-66424 Homburg, Germany.
Claudia GötzDepartment of Medical Biochemistry and Molecular Biology, Saarland University, Kirrberger Str., bldg. 44, D-66424 Homburg, Germany.
Saarland University · DE

Funding

Deutsche Forschungsgemeinschaft CRC 894Dr. Rolf M. Schwiete Stiftung; Mannheim, Germany project Nr. 06/2015Medical Faculty of Saarland University HOMFOR
6 · The paper itself

Abstract

The regulation of insulin biosynthesis and secretion in pancreatic β-cells is essential for glucose homeostasis in humans. Previous findings point to the highly conserved, ubiquitously expressed serine/threonine kinase CK2 as having a negative regulatory impact on this regulation. In the cell culture model of rat pancreatic β-cells INS-1, insulin secretion is enhanced after CK2 inhibition. This enhancement is preceded by a rise in the cytosolic Ca

Indexed as

AnimalsCalciumCalcium Channels, N-TypeCasein Kinase IICell LineInsulinInsulin-Secreting CellsRatsCalciumCalcium Channels, N-TypeCasein Kinase IIInsulinCaV2.1CK2CX-4945INS-1insulin secretion

Identifiers

PMID32630015
PMCPMC7370021
OpenAlexW3040102690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.