Evidence map›Paper›PMID 32629894›Full record

ArticleInternational journal of molecular sciences2020

In Situ Detection of Endogenous HIV Activation by Dynamic Nuclear Polarization NMR and Flow Cytometry.

Sarah A Overall, Lauren E Price, Brice J Albert, Chukun Gao, Nicholas Alaniva, Patrick T Judge, Erika L Sesti, Paul A Wender, George B Kyei, Alexander B Barnes

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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  8. The Physical Chemistry and Chemical Physics (PCCP) Section of theInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Sarah A OverallLaboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Lauren E PriceLaboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Brice J AlbertDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Chukun GaoLaboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Nicholas AlanivaLaboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
Patrick T JudgeDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Erika L SestiDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Paul A WenderDepartments of Chemistry and Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
George B KyeiDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Alexander B BarnesLaboratory of Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland.
ETH Zurich · CHWashington University in St. Louis · USStanford University · USUniversity of Ghana · GH

Funding

SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENTR01CA031845 · NCI · STANFORD UNIVERSITY · PI PAUL Anthony WENDER · 1985 to 2026
$6.9M
HIV latency reversal through novel, potent PKC modulatorsR01AI124743 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WENDER, PAUL ANTHONY, ZACK, JEROME A. · 2016 to 2020
$3.3M
Camille and Henry Dreyfus Foundation Teacher-Scholar AwardNational Institute of Health Director's New Innovator Award DP2GM119131National Science Foundation DBI-1553577NCI NIH HHS R01 CA031845NIAID NIH HHS R01 AI124743NIH HHS CA031845
6 · The paper itself

Abstract

We demonstrate for the first time in-cell dynamic nuclear polarization (DNP) in conjunction with flow cytometry sorting to address the cellular heterogeneity of in-cell samples. Utilizing a green fluorescent protein (GFP) reporter of HIV reactivation, we correlate increased

Indexed as

Flow CytometryHIV InfectionsHumansJurkat CellsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMolecular StructureNitrogen OxidesNuclear Magnetic Resonance, BiomolecularVirus ActivationNitrogen Oxidesnitroxyldynamic nuclear polarizationHIVin-cell NMRsolid-state NMRviral latency

Identifiers

PMID32629894
PMCPMC7369949
OpenAlexW3039070743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.