Evidence map›Paper›PMID 32629864›Full record

ArticlePharmaceutics2020

In Vitro Bioeffects of Polyelectrolyte Multilayer Microcapsules Post-Loaded with Water-Soluble Cationic Photosensitizer.

Alexey V Ermakov, Roman A Verkhovskii, Irina V Babushkina, Daria B Trushina, Olga A Inozemtseva, Evgeny A Lukyanets, Vladimir J Ulyanov, Dmitry A Gorin, Sergei Belyakov, Maria N Antipina

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Alexey V ErmakovInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore.
Roman A VerkhovskiiSaratov State University, Astrakhanskaya St 83, 410012 Saratov, Russia.
Irina V BabushkinaInstitute of Traumatology and Orthopedics, Saratov Medical State University, Chernyshevskaya St 148, 410002 Saratov, Russia.
Daria B TrushinaI.M. Sechenov First Moscow State Medical University, Bol'shaya Pirogovskaya St 19c1, 119146 Moscow, Russia.ORCID 0000-0001-9871-8050
Olga A InozemtsevaSaratov State University, Astrakhanskaya St 83, 410012 Saratov, Russia.
Evgeny A LukyanetsOrganic Intermediates and Dyes Institute, B. Sadovaya St ¼, 101999 Moscow, Russia.
Vladimir J UlyanovInstitute of Traumatology and Orthopedics, Saratov Medical State University, Chernyshevskaya St 148, 410002 Saratov, Russia.
Dmitry A GorinSkolkovo Institute of Science and Technology, Bolshoy Blvd 30, bld. 1, 121205 Moscow, Russia.
Sergei BelyakovTheracross Technologies Pte Ltd, 250p Pasir Panjang Rd, Singapore 117452, Singapore.
Maria N AntipinaInstitute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore.ORCID 0000-0001-8535-5772
Agency for Science, Technology and Research · SGSaratov State Medical University · RUSaratov State University · RURussian Academy of Sciences · RUScientific Research Institute of Organic Intermediates and Dyes · RUSkolkovo Institute of Science and Technology · RU

Funding

Ministry of Science and Higher Education of the Russian Federation MEGAGRANT contract #075-15-2019-1927 dd. 09.12.2019Russian Foundation for Basic Research 19-53-80047
6 · The paper itself

Abstract

Microencapsulation and targeted delivery of cytotoxic and antibacterial agents of photodynamic therapy (PDT) improve the treatment outcomes for infectious diseases and cancer. In many cases, the loss of activity, poor encapsulation efficiency, and inadequate drug dosing hamper the success of this strategy. Therefore, the development of novel and reliable microencapsulated drug formulations granting high efficacy is of paramount importance. Here we report the in vitro delivery of a water-soluble cationic PDT drug, zinc phthalocyanine choline derivative (Cholosens), by biodegradable microcapsules assembled from dextran sulfate (DS) and poly-l-arginine (PArg). A photosensitizer was loaded in pre-formed [DS/PArg]

Indexed as

Cholosensencapsulation efficacyhigh-temperature treatmentphotodynamic therapypolyelectrolyte multilayer microcapsulespost-loading

Identifiers

PMID32629864
PMCPMC7408512
OpenAlexW3039422994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.