Evidence map›Paper›PMID 32629767›Full record

ArticlePharmaceutics2020

Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll.

Federica Bosca, Federica Foglietta, Alberto Gimenez, Roberto Canaparo, Giovanni Durando, Ilaria Andreana, Alessandro Barge, Elena Peira, Silvia Arpicco, Loredana Serpe and 1 more

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In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Federica BoscaDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Federica FogliettaDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Alberto GimenezFaculty of Pharmaceutical and Biochemical Sciences, Universidad Mayor de San Andrés, 3239 La Paz, Bolivia.
Roberto CanaparoDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Giovanni DurandoNational Institute of Metrological Research (INRIM), 10135 Torino, Italy.
Ilaria AndreanaDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Alessandro BargeDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0003-4638-6634
Elena PeiraDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Silvia ArpiccoDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Loredana SerpeDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Barbara StellaDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sonodynamic therapy is an emerging approach that uses low-intensity ultrasound to activate a sonosensitizer agent triggering its cytotoxicity for selective cancer cell killing. Several molecules have been proposed as sonosensitizer agents, but most of these, as chlorophyll, are strongly hydrophobic with a low selectivity towards cancer tissues. Nanocarriers can help to deliver more efficiently the sonosensitizer agents in the target tumor site, increasing at the same time their sonodynamic effect, since nanosystems act as cavitation nuclei. Herein, we propose the incorporation of unmodified plant-extracted chlorophyll into nanocarriers with different composition and structure (i.e., liposomes, solid lipid nanoparticles and poly(lactic-

Indexed as

cancerchlorophyllliposomesPLGAsolid lipid nanoparticlessonodynamic treatmentsonosensitizerultrasound

Identifiers

PMID32629767
PMCPMC7408081

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.