Evidence map›Paper›PMID 32629543›Full record

ArticleCancer science2020

Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer.

Masatoshi Kochi, Takao Hinoi, Hiroaki Niitsu, Masashi Miguchi, Yasufumi Saito, Haruki Sada, Kazuhiro Sentani, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. EmergingGenes · 2020
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Masatoshi KochiDepartment of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID https://orcid.org/0000-0002-2113-1734
Takao HinoiDepartment of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID https://orcid.org/0000-0003-0462-6177
Hiroaki NiitsuDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Masashi MiguchiDepartment of Gastroenterological, Breast and Transplant Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Yasufumi SaitoDepartment of Surgery, Chugoku Rosai Hospital, Hiroshima, Japan.ORCID https://orcid.org/0000-0002-0407-7684
Haruki SadaDepartment of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kazuhiro SentaniDepartment of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.ORCID https://orcid.org/0000-0002-8987-5414
Naoya SakamotoDepartment of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Naohide OueDepartment of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Hirotaka TashiroDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
Yusuke SotomaruNatural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan.
Wataru YasuiDepartment of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.ORCID https://orcid.org/0000-0002-8647-8405
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hiroshima University · JPChugoku Rosai Hospital · JPHiroshima Prefectural Hospital · JPNational Hospital Organization · JPVanderbilt University Medical Center · US

Funding

Japan Society for the Promotion of Science JP18K08694Japan Society for the Promotion of Science JP22390257Japan Society for the Promotion of Science JP25293284
6 · The paper itself

Abstract

BRAF

Indexed as

AnimalsCaco-2 CellsCarcinogenesisCell Line, TumorCell ProliferationColorectal NeoplasmsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansMCF-7 CellsMiceMice, Inbred BALB CMice, NudeMutationNeoplasm ProteinsGREB1 protein, humanNeoplasm ProteinsProto-Oncogene Proteins B-rafraf Kinasesras ProteinsBRAF mutationcolorectal cancerERGREB1mouse model

Identifiers

PMID32629543
PMCPMC7541019
OpenAlexW3041944054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.